Advances in yeast synthetic biology for human G protein-coupled receptor biology and pharmacology

被引：0
|
作者：
Kapolka, Nicholas J. [1 ]
Taghon, Geoffrey J. [2 ]
Isom, Daniel G. [3 ,4 ,5 ]
机构：
[1] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC USA
[2] Natl Inst Stand & Technol, Gaithersburg, MD USA
[3] Univ Miami, Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33136 USA
[4] Sylvester Comprehens Canc Ctr, Tumor Biol Program, Miami, FL 33136 USA
[5] Frost Inst Data Sci & Comp, Coral Gables, FL 33146 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2024年 / 88卷
基金：
美国国家卫生研究院;
关键词：
A-FACTOR; GPCR; PATHWAYS; LIGANDS; ARREST; ASSAYS;
D O I：
10.1016/j.copbio.2024.103176
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
G protein-coupled receptors (GPCRs) are the largest family of regulate the (patho)biology of every organ, tissue, and cell type. Consequently, GPCRs are the most prominent therapeutic targets in medicine. Although over 30% of current U.S. Food signaling, most receptors remain understudied and therapeutically underutilized. Challenges include an incomplete understanding of GPCR signaling, pharmacology, structural biology, and the multiplicity of endogenous GPCR ligands, in addition to a scarcity of biological and pharmacological tools for elucidating GPCR-mediated cellular processes beyond initial signaling events. Various mammalian, insect, and yeast cell models currently address some of these needs. Here, we review recent advances in yeast synthetic biology that are helping to catalyze new and unexpected conceptual and technical breakthroughs in GPCR-based medicine and biotechnology.
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页数：7
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