A systematic review: Sinomenine

被引：2
作者：
Jiang, Shan [1 ,2 ]
Li, Shuang [2 ,3 ]
Pang, Siyuan [4 ]
Liu, Mei [5 ]
Sun, Huifeng [1 ]
Zhang, Ning [1 ]
Liu, Jianxin [2 ,5 ,6 ,7 ]
机构：
[1] Heilongjiang Univ Tradit Chinese Med, Sch Pharm, Harbin 150040, Heilongjiang, Peoples R China
[2] Hunan Univ Med, Sino Pakistan Ctr Tradit Chinese Med, Sch Pharmaceut Sci, Huaihua 418000, Hunan, Peoples R China
[3] Jiamusi Univ, Coll Pharm, Jiamusi 154000, Heilongjiang, Peoples R China
[4] Hunan Zhengqing Pharmaceut Co Grp Ltd, Huaihua 418000, Hunan, Peoples R China
[5] Univ South China, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China
[6] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha 410208, Hunan, Peoples R China
[7] Hunan Univ Med, Sch Pharmaceut Sci, Huaihua 418000, Hunan, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 09期
关键词：
Natural compound; Sinomenine; Rheumatoid arthritis; Pharmacological mechanism; Chronic inflammatory diseases; Therapeutic drugs; COLLAGEN-INDUCED ARTHRITIS; BREAST-CANCER CELLS; RHEUMATOID-ARTHRITIS; EXPRESSION; PROLIFERATION; INFLAMMATION; ACTIVATION; APOPTOSIS; RECEPTOR; PHARMACOLOGY;
D O I：
10.1016/j.heliyon.2024.e29976
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sinomenine (SIN), an alkaloid derived from the traditional Chinese medicine, Caulis Sinomenii , has been used as an anti-inflammatory drug in China for over 30 years. With the continuous increase in research on the pharmacological mechanism of SIN, it has been found that, in addition to the typical rheumatoid arthritis (RA) treatment, SIN can be used as a potentially effective therapeutic drug for anti -tumour, anti -renal, and anti -nervous system diseases. By reviewing a large amount of literature and conducting a summary analysis of the literature pertaining to the pharmacological mechanism of SIN, we completed a review that focused on SIN, found that the current research is insufficient, and offered an outlook for future SIN development. We hope that this review will increase the public understanding of the pharmacological mechanisms of SIN, discover SIN research trial shortcomings, and promote the effective treatment of immune diseases, inflammation, and other related diseases.
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页数：16
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