Potential clinical applications of extracellular vesicles in pancreatic cancer: exploring untapped opportunities from biomarkers to novel therapeutic approaches

被引：1
作者：
Sanchez-Manas, Jose Manuel [1 ,2 ]
de Gracia, Natalia Perez [2 ]
Perales, Sonia [1 ,2 ,3 ]
Martinez-Galan, Joaquina [3 ,4 ]
Torres, Carolina [1 ,3 ,5 ]
Real, Pedro J. [1 ,2 ,3 ]
机构：
[1] Pfizer Univ Granada Andalusian Reg Govt, Ctr Genom & Oncol Res, Gene Regulat Stem Cells & Dev lab, GENyO,PTS, Granada 18016, Spain
[2] Univ Granada, Fac Sci, Dept Biochem & Mol Biol 1, Granada 18071, Spain
[3] Inst Invest Biosanit ibs GRANADA, Granada 18012, Spain
[4] Virgen de las Nieves Univ Hosp, Dept Med Oncol, Granada 18014, Spain
[5] Univ Granada, Fac Med, Dept Biochem & Mol Biol & Immunol 3, Granada, Spain
来源：
EXTRACELLULAR VESICLES AND CIRCULATING NUCLEIC ACIDS | 2024年 / 5卷 / 02期
关键词：
Extracellular vesicles; pancreatic cancer; liquid biopsy; diagnosis biomarkers; CIRCULATING EXOSOMES; MUTANT KRAS; CELLS; DNA; METASTASIS; INHIBITION; GENERATION;
D O I：
10.20517/evcna.2023.68
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic cancer is a highly lethal and metastatic malignancy, mainly because it often remains undetected until advanced stages due to the limitations of current diagnostic methods, rendering currently available therapies ineffective. Therefore, it is imperative to identify useful biomarkers for early diagnosis and new therapeutic targets for pancreatic cancer. Recently, extracellular vesicles have emerged as promising biomarkers for the diagnosis and prognosis of pancreatic cancer. Given their presence in various bodily fluids, extracellular vesicles offer a noninvasive approach through liquid biopsy to detect and monitor cancer progression. In this review, we comprehensively examine the multifaceted roles of extracellular vesicles in the progression of cancer, while also exploring their potential as diagnostic, prognostic, and therapeutic biomarkers in the context of pancreatic cancer.
引用
收藏
页码：180 / 200
页数：21
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