Synergistic Mechanisms of Selected Polyphenols in Overcoming Chemoresistance and Enhancing Chemosensitivity in Colorectal Cancer

被引:2
|
作者
Hon, Kha Wai [1 ]
Naidu, Rakesh [1 ]
机构
[1] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul, Malaysia
关键词
chemoresistance; colorectal cancer; flavonoids; polyphenols; synergistic mechanisms; signaling pathways; TO-MESENCHYMAL TRANSITION; NF-KAPPA-B; COLON-CANCER; IN-VITRO; ANTICANCER ACTIVITY; WNT/BETA-CATENIN; MISMATCH REPAIR; CLINICOPATHOLOGICAL FEATURES; MICROSATELLITE INSTABILITY; CHEMOTHERAPEUTIC DRUGS;
D O I
10.3390/antiox13070815
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Despite significant advances in medical treatment, chemotherapy as monotherapy can lead to substantial side effects and chemoresistance. This underscores the need for therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways and sensitize cancer cells to overcome resistance to standard drugs. In recent years, scientists have been searching for natural compounds that can be used as chemosensitizers in addition to conventional medications for the synergistic treatment of CRC. Polyphenols represent a diverse group of natural compounds that can target multiple signaling pathways in cancer cells to induce anti-cancer effects. Additionally, polyphenols have been shown to work synergistically with chemotherapeutics and other natural compounds in cancer cells. This review aims to provide a comprehensive insight into the synergistic mechanisms of selected polyphenols as chemosensitizers in CRC cells. Further research and clinical trials are warranted to fully harness the synergistic mechanisms of selected polyphenols combined with chemotherapy or natural compounds in improving cancer treatment outcomes.
引用
收藏
页数:40
相关论文
共 22 条
  • [1] Strategies in overcoming the chemoresistance in colorectal cancer
    Vodenkova, Sona
    Buchler, Tomas
    Vymetalkova, Veronika
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [2] Overcoming chemoresistance in cancer stem cells with the help of microRNAs in colorectal cancer
    Fesler, Andrew
    Guo, Shixiang
    Liu, Hua
    Wu, Ning
    Ju, Jingfang
    EPIGENOMICS, 2017, 9 (06) : 793 - 796
  • [3] Overcoming antiapoptotic responses to promote chemosensitivity in metastatic colorectal cancer to the liver
    Cusack, JC
    ANNALS OF SURGICAL ONCOLOGY, 2003, 10 (08) : 852 - 862
  • [4] Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells
    Liu, Zhuo
    Yu, Miao
    Fei, Bingyuan
    Sun, Jing
    Wang, Dongxin
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 13 : 3823 - 3834
  • [5] Overcoming Antiapoptotic Responses to Promote Chemosensitivity in Metastatic Colorectal Cancer to the Liver
    James C. Cusack
    Annals of Surgical Oncology, 2003, 10 : 852 - 862
  • [6] DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer
    Ying Chen
    Muxing Kang
    Wenjie Lu
    Qingqu Guo
    Bo Zhang
    Qiuping Xie
    Yulian Wu
    Journal of Cancer Research and Clinical Oncology, 2012, 138 : 1463 - 1474
  • [7] DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer
    Chen, Ying
    Kang, Muxing
    Lu, Wenjie
    Guo, Qingqu
    Zhang, Bo
    Xie, Qiuping
    Wu, Yulian
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2012, 138 (09) : 1463 - 1474
  • [8] Overcoming sternness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling
    Jin, Yinghu
    Wang, Meng
    Hu, Hanging
    Huang, Quanlong
    Chen, Yinggang
    Wang, Guiyu
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 117 : 445 - 453
  • [9] Overcoming chemoresistance in non-angiogenic colorectal cancer by metformin via inhibiting endothelial apoptosis and vascular
    Li, Guang-Yue
    Zhang, Shu-Jing
    Xue, Dong
    Feng, Yue-Qi
    Li, Yan
    Huang, Xun
    Cui, Qiang
    Wang, Bo
    Feng, Jun
    Bao, Tao
    Liu, Pei-Jun
    Lu, Shao-Ying
    Wang, Ji-Chang
    JOURNAL OF PHARMACEUTICAL ANALYSIS, 2023, 13 (03) : 262 - 275
  • [10] Selected Aspects of Chemoresistance Mechanisms in Colorectal CarcinomaA Focus on Epithelial-to-Mesenchymal Transition, Autophagy, and Apoptosis
    Skarkova, Veronika
    Kralova, Vera
    Vitovcova, Barbora
    Rudolf, Emil
    CELLS, 2019, 8 (03)