How reliable is assessment of true vocal cord-arytenoid unit mobility in patients affected by laryngeal cancer? a multi-institutional study on 366 patients from the ARYFIX collaborative group

被引：4

作者：

Ferrari, M. ^{[1
,34
]}

Mularoni, F. ^{[1
]}

Taboni, S. ^{[1
]}

Crosetti, E. ^{[2
]}

Pessina, C. ^{[3
]}

Carobbio, A. L. C. ^{[1
]}

Montalto, N. ^{[1
]}

Marchi, F. ^{[4
,5
]}

Vural, A. ^{[6
]}

Paderno, A. ^{[7
]}

Caprioli, S. ^{[8
]}

Gaudioso, P. ^{[1
]}

Fermi, M. ^{[9
,10
]}

Rigoni, F. ^{[1
]}

Saccardo, T. ^{[1
]}

Contro, G. ^{[1
]}

Ruaro, A. ^{[1
]}

Lo Manto, A. ^{[8
]}

Varago, C. ^{[9
]}

Baldovin, M. ^{[10
,13
]}

Bandolin, L. ^{[11
,14
]}

Filauro, M.

Sampieri, C. ^{[12
,15
,16
]}

Missale, F. ^{[17
]}

Ioppi, A. ^{[18
]}

Carta, F. ^{[19
]}

Ramanzin, M. ^{[20
]}

Ravanelli, M. ^{[21
]}

Maiolo, V ^{[22
]}

Bertotto, I. ^{[23
]}

Del Bon, F. ^{[24
]}

Lancini, D. ^{[24
]}

Mariani, C. ^{[19
]}

Marrosu, V ^{[19
]}

Tatti, M. ^{[19
]}

Cagli, S. ^{[25
]}

Yuce, I. ^{[25
]}

Gundog, M. ^{[26
]}

Dogan, S. ^{[27
]}

Anile, G. ^{[28
]}

Gottardi, C. ^{[28
]}

Busato, F. ^{[29
]}

Vallin, A. ^{[4
,5
]}

Gennarini, F.

Bossi, P. ^{[7
,30
,31
]}

Ghi, M. G. ^{[28
]}

Lionello, M. ^{[12
]}

Zanoletti, E. ^{[1
]}

Marioni, G. ^{[1
]}

Maroldi, R. ^{[21
]}

机构：

[1] Azienda Osped Univ Padova, Dept Neurosci, Otorhinolaryngol & Head & Neck Unit, Padua, Italy

[2] San Giovanni Bosco Hosp, Otorhinolaryngol Dept, Head Neck Canc Unit, Turin, Italy

[3] Univ Padua, St Antonio Hosp, Radiol Unit, Padua, Italy

[4] IRCCS Osped Policlin San Martino, Unit Otorhinolaryngol Head & Neck Surg, Largo Rosanna Benzi 10, I-16121 Genoa, Italy

[5] Univ Genoa, Dept Surg Sci & Integrated Diagnost DISC, Genoa, Italy

[6] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Otorhinolaryngol Unit, Istanbul, Turkiye

[7] IRCCS Humanitas Res Hosp, Neurosurg Dept, via Manzoni 56, I-20089 Milan, Italy

[8] San Martino Hosp, Radiol Unit, Genoa, Italy

[9] Otorhinolaryngol Unit, Azienda Osped Univ Bologna IRCCS, Bologna, Italy

[10] Univ Bologna, Dept Surg & Med Sci, Bologna, Italy

[11] Infermi Hosp, Otorhinolaryngol Unit, Rimini, Italy

[12] Vittorio Veneto Hosp, Otorhinolaryngol Unit, Treviso, Italy

[13] San Martino di Belluno Hosp, Otorhinolaryngol Unit, Belluno, Italy

[14] Hosp Santorso, Otorhinolaryngol Unit, Vicenza, Italy

[15] Univ Genoa, Dept Expt Med DIMES, Genoa, Italy

[16] Hosp Clin Barcelona, Unit Head & Neck Tumors, Barcelona, Spain

[17] Maastricht Univ, Dept Otorhinolaryngol Head & Neck Surg, Med Ctr, NL-6202 AZ Maastricht, Netherlands

[18] Santa Chiara Hosp, Dept Otorhinolaryngol Head & Neck Surg, Azienda Prov & Serv Sanit APSS, Trento, Italy

[19] Otorhinolaryngol Unit, Azienda Osped Univ Cagliari, Cagliari, Italy

[20] Hosp Vicenza, Radiol Unit, Vicenza, Italy

[21] Univ Brescia, Radiol Unit, ASST Spedali Civili Brescia, Brescia, Italy

[22] Univ Bologna, Pediat & Adult Cardiothorac & Vasc Oncohematol &, IRCCS AOUBO, Bologna, Italy

[23] IRCCS Ist Candiolo, Radiol Unit, Turin, Italy

[24] Univ Brescia, Otorhinolaryngol Unit, ASST Spedali Civili Brescia, Brescia, Italy

[25] Erciyes Univ, Otorhinolaryngol Unit, Kayseri, Turkiye

[26] Erciyes Univ, Dept Radiat Oncol, Kayseri, Turkiye

[27] Erciyes Univ, Dept Radiol, Kayseri, Turkiye

[28] Ist Oncol Veneto, Unit Med Oncol 2, Padua, Italy

[29] Unit Radiat Oncol, Policlin Abano, Padua, Italy

[30] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Milan, Italy

[31] Univ Modena, Otorhinolaryngol Unit, Modena, Italy

[32] Kings Coll Hosp London, Dubai, U Arab Emirates

[33] Univ Turin, Oncol Dept, Turin, Italy

[34] Univ Padua, Azienda Osped Univ Padova, Dept Neurosci, Sect Otorhinolaryngol Head & Neck Surg, Via Giustiniani 2, Padua 35128, Italy

来源：

ORAL ONCOLOGY | 2024年 / 152卷

关键词：

Larynx; Squamous cell carcinoma; Arytenoid; Vocal cord; Mobility; Endoscopy; Imaging; Agreement; Reliability; SUPRACRICOID PARTIAL LARYNGECTOMY; INDUCTION CHEMOTHERAPY; NEOADJUVANT CHEMOTHERAPY; GLOTTIC CARCINOMA; PROGNOSTIC-FACTOR; FIXATION; CANCER; CRICOHYOIDOEPIGLOTTOPEXY; NOMENCLATURE; SURVIVAL;

D O I：

10.1016/j.oraloncology.2024.106744

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: In clinical practice the assessment of the "vocal cord-arytenoid unit " (VCAU) mobility is crucial in the staging, prognosis, and choice of treatment of laryngeal squamous cell carcinoma (LSCC). The aim of the present study was to measure repeatability and reliability of clinical assessment of VCAU mobility and radiologic analysis of posterior laryngeal extension. Methods: In this multi -institutional retrospective study, patients with LSCC-induced impairment of VCAU mobility who received curative treatment were included; pre-treatment endoscopy and contrast -enhanced imaging were collected and evaluated by raters. According to their evaluations, concordance, number of assigned categories, and inter- and intra-rater agreement were calculated. Results: Twenty-two otorhinolaryngologists evaluated 366 videolaryngoscopies (total evaluations: 2170) and 6 radiologists evaluated 237 imaging studies (total evaluations: 477). The concordance of clinical rating was excellent in only 22.7% of cases. Overall, inter- and intra-rater agreement was weak. Supraglottic cancers and transoral endoscopy were associated with the lowest inter -observer reliability values. Radiologic inter -rater agreement was low and did not vary with imaging technique. Intra-rater reliability of radiologic evaluation was optimal. Conclusions: The current methods to assess VCAU mobility and posterior extension of LSCC are flawed by weak inter -observer agreement and reliability. Radiologic evaluation was characterized by very high intra-rater agreement, but weak inter -observer reliability. The relevance of VCAU mobility assessment in laryngeal oncology should be re -weighted. Patients affected by LSCC requiring imaging should be referred to dedicated radiologists with experience in head and neck oncology.

引用

页数：10