Clinicopathologic Features of Gastrointestinal Tract Langerhans Cell Histiocytosis

被引：1

作者：

Hu, Shaomin ^{[1
]}

Graham, Rondell P. ^{[2
]}

Choi, Won-Tak ^{[3
]}

Wen, Kwun Wah ^{[3
]}

Putra, Juan ^{[4
]}

Chen, Wei ^{[5
]}

Lin, Jingmei ^{[6
]}

Gonzalez, Ivan A. ^{[6
]}

Panarelli, Nicole ^{[7
]}

Liu, Qiang ^{[7
]}

Zhao, Lei ^{[8
]}

Gong, Shunyou ^{[9
]}

Mejia-Bautista, Melissa ^{[9
]}

Escobar, David J. ^{[9
]}

Ma, Changqing ^{[10
,11
]}

Shalaby, Akram ^{[10
,12
]}

Du, Xiaotang ^{[13
]}

Kang, Liang-, I ^{[14
]}

Zhang, Wei ^{[15
,16
]}

Chen, Xiuxu ^{[17
]}

Ding, Xianzhong ^{[17
]}

Chen, Hannah H. ^{[18
]}

Ye, Zhan ^{[19
]}

Pezhouh, Maryam K. ^{[20
]}

Liao, Xiaoyan ^{[21
]}

Liu, Yongjun ^{[22
]}

Yang, Zhaohai ^{[23
]}

Alpert, Lindsay ^{[24
]}

Hart, John ^{[24
]}

Goldblum, John R. ^{[1
]}

Allende, Daniela ^{[1
]}

Zheng, Wei ^{[25
]}

Gonzalez, Raul S. ^{[25
]}

Wang, Hanlin L. ^{[13
]}

Zhang, Xuchen ^{[26
]}

Liu, Xiuli ^{[14
]}

Longacre, Teri ^{[27
]}

Westerhoff, Maria ^{[28
]}

Xue, Yue ^{[9
,12
]}

机构：

[1] Cleveland Clin, Dept Pathol, Cleveland, OH USA

[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55906 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA

[4] Boston Childrens Hosp, Dept Pathol, Boston, MA USA

[5] Ohio State Univ, Wexner Med Ctr, Dept Pathol, Columbus, OH USA

[6] Indiana Univ, Dept Pathol & Lab Med, Indianapolis, IN 46204 USA

[7] Montefiore Med Ctr, Dept Pathol, Bronx, NY 10461 USA

[8] Brigham & Womens Hosp, Dept Pathol, Boston, MA USA

[9] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

[10] Univ Pittsburg Med Ctr, Dept Pathol, Pittsburgh, PA USA

[11] Washington Univ, Dept Pathol & Immunol, St Louis, MO USA

[12] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[13] UCLA, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA USA

[14] Washington Univ, Dept Pathol & Immunol, St Louis, MO USA

[15] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI USA

[16] Univ Kansas Med Ctr, Dept Pathol & Lab Med, Kansas City, KS USA

[17] Loyola Univ Med Ctr, Dept Pathol & Lab Med, Chicago, IL USA

[18] Tufts Med Ctr, Dept Pathol & Lab Med, Boston, MA USA

[19] Univ Kansas Med Ctr, Dept Pathol & Lab Med, Kansas City, KS USA

[20] Univ Calif San Diego, Dept Pathol, San Diego, CA USA

[21] Univ Rochester, Dept Pathol & Lab Med, Rochester, NY USA

[22] Univ Washington Med Ctr, Dept Lab Med & Pathol, Seattle, WA 98195 USA

[23] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA USA

[24] Univ Chicago, Dept Pathol, Chicago, IL USA

[25] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[26] Yale Sch Med, Dept Pathol, New Haven, CT USA

[27] Stanford Univ, Dept Pathol, Stanford, CA USA

[28] Univ Michigan, Dept Pathol, Ann Arbor, MI USA

来源：

MODERN PATHOLOGY | 2024年 / 37卷 / 09期

关键词：

adult; gastrointestinal; Langerhans cell histiocytosis; pediatric; INVOLVEMENT;

D O I：

10.1016/j.modpat.2024.100543

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gastrointestinal (GI) tract involvement by Langerhans cell histiocytosis (LCH) is rare and its clinicopathologic characteristics have only been described in case reports and small series. We reviewed hematoxylin and eosin and CD1a, S100, and Langerin immunohistochemicalestained slides from 47 patients with well-documented demographic and clinical findings. Our cases included 8 children and 39 adults, with a mean follow-up of 63 months. All pediatric patients had concurrent multisystem LCH, presented with GI symptoms, and showed nonpolypoid lesions. Seven (88%) showed multifocal GI disease, including 5 with multiple GI organ involvement. All sampled lesions from children exhibited infiltrative growth. More than half had died of the disease or manifested persistent LCH at last follow-up. Twenty-five of 39 (64%) adults had LCH involving only the GI tract (single system), with the remaining 14 (36%) exhibiting multisystem disease. Adult single-system GI LCH was typically encountered incidentally on screening/surveillance endoscopy (72%). Most exhibited isolated colorectal involvement (88%) as a solitary polyp (92%), with a well-demarcated/ noninfiltrative growth pattern (70%), and excellent prognosis (10 0%). In comparison, adult

引用

页数：6

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