The transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has the potential to overcome some of the major disadvantages relating to oral NSAID usage, such as gastrointestinal adverse events and compliance. However, the poor solubility of many of the newer NSAIDs creates challenges in incorporating the drugs into formulations suitable for application to skin and may limit transdermal permeation, particularly if the goal is therapeutic systemic drug concentrations. This review is an overview of the various strategies used to increase the solubility of poorly soluble NSAIDs and enhance their permeation through skin, such as the modification of the vehicle, the modification of or bypassing the barrier function of the skin, and using advanced nano-sized formulations. Furthermore, the simple yet highly versatile microemulsion system has been found to be a cost-effective and highly successful technology to deliver poorly water-soluble NSAIDs.
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Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge CB2 0SP, EnglandHarvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
Young, Adam M. H.
Karri, Surya K.
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Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
Karri, Surya K.
Ogilvy, Christopher S.
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Harvard Med Sch, Massachusetts Gen Hosp, Endovasc & Operat Neurovasc Surg, Boston, MA 02114 USA
Harvard Med Sch, Massachusetts Gen Hosp, Neurosurg, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
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Cooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, IndiaCooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, India
Bindu, Samik
Mazumder, Somnath
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CSIR, Div Infect Dis & Immunol, Indian Inst Chem Biol, 4 Raja SC Mullick Rd, Kolkata 700032, W Bengal, India
Natl Inst Biomed Genom, PO NSS, Kalyani 741251, W Bengal, IndiaCooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, India
Mazumder, Somnath
Bandyopadhyay, Uday
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CSIR, Div Infect Dis & Immunol, Indian Inst Chem Biol, 4 Raja SC Mullick Rd, Kolkata 700032, W Bengal, India
Bose Inst, Div Mol Med, P-1-12,CIT Rd,Scheme VIIM, Kolkata 700054, W Bengal, IndiaCooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, India
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Kings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, EnglandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England
Bowers, Megan
Cucchiaro, Brittany
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UCL, Fac Med Sci, Div Med, London WC1E 6BT, England
Univ Coll London Hosp NHS Fdn Trust, London, EnglandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England
Cucchiaro, Brittany
Reid, Joanne
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Queens Univ Belfast, Med Biol Ctr, Sch Nursing & Midwifery, Belfast, North IrelandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England
Reid, Joanne
Slee, Adrian
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UCL, Fac Med Sci, Div Med, London WC1E 6BT, EnglandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England
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Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge CB2 0SP, EnglandHarvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
Young, Adam M. H.
Karri, Surya K.
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h-index: 0
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Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
Karri, Surya K.
Ogilvy, Christopher S.
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h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Endovasc & Operat Neurovasc Surg, Boston, MA 02114 USA
Harvard Med Sch, Massachusetts Gen Hosp, Neurosurg, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, 55 Fruit St,Wang 745Z, Boston, MA 02114 USA
机构:
Cooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, IndiaCooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, India
Bindu, Samik
Mazumder, Somnath
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机构:
CSIR, Div Infect Dis & Immunol, Indian Inst Chem Biol, 4 Raja SC Mullick Rd, Kolkata 700032, W Bengal, India
Natl Inst Biomed Genom, PO NSS, Kalyani 741251, W Bengal, IndiaCooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, India
Mazumder, Somnath
Bandyopadhyay, Uday
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机构:
CSIR, Div Infect Dis & Immunol, Indian Inst Chem Biol, 4 Raja SC Mullick Rd, Kolkata 700032, W Bengal, India
Bose Inst, Div Mol Med, P-1-12,CIT Rd,Scheme VIIM, Kolkata 700054, W Bengal, IndiaCooch Behar Panchanan Barma Univ, Dept Zool, Cooch Behar 736101, W Bengal, India
机构:
Kings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, EnglandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England
Bowers, Megan
Cucchiaro, Brittany
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UCL, Fac Med Sci, Div Med, London WC1E 6BT, England
Univ Coll London Hosp NHS Fdn Trust, London, EnglandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England
Cucchiaro, Brittany
Reid, Joanne
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Queens Univ Belfast, Med Biol Ctr, Sch Nursing & Midwifery, Belfast, North IrelandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England
Reid, Joanne
Slee, Adrian
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UCL, Fac Med Sci, Div Med, London WC1E 6BT, EnglandKings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, Cicely Saunders Inst Palliat Care Policy & Rehabil, London, England