Strategies to Improve the Transdermal Delivery of Poorly Water-Soluble Non-Steroidal Anti-Inflammatory Drugs

被引:3
|
作者
Balmanno, Alexandra [1 ]
Falconer, James R. [2 ]
Ravuri, Halley G. [3 ]
Mills, Paul C. [1 ]
机构
[1] Univ Queensland, Sch Vet Sci, Gatton Campus, Gatton, Qld 4343, Australia
[2] Univ Queensland, Sch Pharm, Dutton Pk Campus, Woolloongabba, Qld 4102, Australia
[3] Univ Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia
关键词
transdermal; microemulsion; NSAID; nanoformulation; MICROEMULSION-BASED HYDROGEL; SOLID LIPID NANOPARTICLES; SUPERCRITICAL CARBON-DIOXIDE; IN-VIVO EVALUATION; PENETRATION ENHANCERS; SKIN PERMEATION; OLEIC-ACID; EX-VIVO; PHYSICOCHEMICAL CHARACTERIZATION; PERCUTANEOUS-ABSORPTION;
D O I
10.3390/pharmaceutics16050675
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has the potential to overcome some of the major disadvantages relating to oral NSAID usage, such as gastrointestinal adverse events and compliance. However, the poor solubility of many of the newer NSAIDs creates challenges in incorporating the drugs into formulations suitable for application to skin and may limit transdermal permeation, particularly if the goal is therapeutic systemic drug concentrations. This review is an overview of the various strategies used to increase the solubility of poorly soluble NSAIDs and enhance their permeation through skin, such as the modification of the vehicle, the modification of or bypassing the barrier function of the skin, and using advanced nano-sized formulations. Furthermore, the simple yet highly versatile microemulsion system has been found to be a cost-effective and highly successful technology to deliver poorly water-soluble NSAIDs.
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页数:27
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