Cardiac resident macrophages: The core of cardiac immune homeostasis

被引：4

作者：

Cai, Wenhui ^{[1
,2
,3
]}

Lian, Lu ^{[1
,2
,3
]}

Li, Aolin ^{[1
,2
,3
]}

Zhang, Qianqian ^{[3
]}

Li, Mengmeng ^{[3
]}

Zhang, Junping ^{[1
]}

Xie, Yingyu ^{[4
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, First Teaching Hosp, Tianjin 300183, Peoples R China

[2] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin 300193, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China

[4] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China

来源：

CELLULAR SIGNALLING | 2024年 / 119卷

基金：

中国国家自然科学基金;

关键词：

Cardiac resident macrophages; Myocardial injury; Immune homeostasis; Inflammation; STEADY-STATE; SUCCINATE-DEHYDROGENASE; HEART; CELL; MONOCYTES; REPAIR; EFFEROCYTOSIS; PHAGOCYTOSIS; CLEARANCE; GOVERNS;

D O I：

10.1016/j.cellsig.2024.111169

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiac resident macrophages (CRMs) are essential in maintaining the balance of the immune homeostasis in the heart. One of the main factors in the progression of cardiovascular diseases, such as myocarditis, myocardial infarction(MI), and heart failure(HF), is the imbalance in the regulatory mechanisms of CRMs. Recent studies have reported novel heterogeneity and spatiotemporal complexity of CRMs, and their role in maintaining cardiac immune homeostasis and treating cardiovascular diseases. In this review, we focus on the functions of CRMs, including immune surveillance, immune phagocytosis, and immune metabolism, and explore the impact of CRM's homeostasis imbalance on cardiac injury and cardiac repair. We also discuss the therapeutic approaches linked to CRMs. The immunomodulatory strategies targeting CRMs may be a therapeutic approach for the treatment of cardiovascular disease.

引用

页数：11

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