Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases

被引：4

作者：

Zhao, Pengxuan ^{[1
,2
]}

Wu, Tiantian ^{[2
]}

Tian, Yu ^{[3
]}

You, Jia ^{[2
]}

Cui, Xinwu ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Med Ultrasound, Wuhan 430030, Peoples R China

[2] Hainan Med Univ, Int Joint Res Ctr Human machine Intelligent Collab, Sch Pharm, Hainan Prov Key Lab Res & Dev Trop Herbs, Haikou 571199, Peoples R China

[3] Jiangsu Hengrui Pharmaceut Co Ltd, Shanghai 200000, Peoples R China

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2024年 / 209卷

基金：

中国国家自然科学基金;

关键词：

Focused ultrasound; Microbubbles; Blood -brain barrier; Cavitation effect; Neurodegenerative diseases; Clinical applications; PARKINSONS-DISEASE; NEUROTROPHIC FACTOR; DRUG-DELIVERY; INTRAARTERIAL CHEMOTHERAPY; ALZHEIMER-DISEASE; GENE DELIVERY; DOUBLE-BLIND; MOUSE MODEL; IN-VIVO; DISRUPTION;

D O I：

10.1016/j.addr.2024.115323

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the aging population on the rise, neurodegenerative disorders have taken center stage as a significant health concern. The blood-brain barrier (BBB) plays an important role to maintain the stability of central nervous system, yet it poses a formidable obstacle to delivering drugs for neurodegenerative disease therapy. Various methods have been devised to confront this challenge, each carrying its own set of limitations. One particularly promising noninvasive approach involves the utilization of focused ultrasound (FUS) combined with contrast agents-microbubbles (MBs) to achieve transient and reversible BBB opening. This review provides a comprehensive exploration of the fundamental mechanisms behind FUS/MBs-mediated BBB opening and spotlights recent breakthroughs in its application for neurodegenerative diseases. Furthermore, it addresses the current challenges and presents future perspectives in this field.

引用

页数：13