Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact

被引：6

作者：

Vidaurre, Rodrigo ^{[1
]}

Bramke, Irene ^{[2
]}

Puhlmann, Neele ^{[3
]}

Owen, Stewart F. ^{[4
]}

Angst, Daniela ^{[5
]}

Moermond, Caroline ^{[6
]}

Venhuis, Bastiaan ^{[7
]}

Lombardo, Anna ^{[8
]}

Kammerer, Klaus ^{[3
]}

Sikanen, Tiina ^{[9
]}

Ryan, Jim ^{[1
,10
]}

Haener, Andreas ^{[1
,11
]}

Janer, Gemma ^{[1
,2
,12
]}

Roggo, Silvio ^{[5
]}

Perkins, Alison Nimrod ^{[1
,3
,13
]}

机构：

[1] Ecol Inst gGmbH, Berlin, Germany

[2] AstraZeneca BV, The Hague, Netherlands

[3] Leuphana Univ Luneburg, Inst Sustainable Chem, Luneburg, Germany

[4] AstraZeneca, Macclesfield, England

[5] Novartis Pharm AG, Biomed Res, Basel, Switzerland

[6] Natl Inst PublicHealth & Environm RIVM, Ctr Safety Subst & Prod, Bilthoven, Netherlands

[7] Natl Inst Publ Hlth & Environm RIVM, Ctr Hlth Protect, Bilthoven, Netherlands

[8] Ist Ric Farmacol Mario Negri IRCSS, Dept Environm Hlth Sci, Lab Environm Toxicol & Chem, Milan, Italy

[9] Univ Helsinki, Fac Pharm, Drug Res Program, Helsinki, Finland

[10] GSK, EHSS Shared Serv, Stevenage, England

[11] F Hoffmann La Roche Ltd, Grp Safety, Secur Hlth & Environm Protect SHE, Basel, Switzerland

[12] Novartis Pharm, Global HSE, Barcelona, Spain

[13] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN USA

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 07期

基金：

欧盟地平线“2020”;

关键词：

persistence; bioaccumulation; ecotoxicity; chemical mobility; safe and sustainable by design SSbD; environmentally benign; human health; BIOCONCENTRATION FACTORS; CONSERVATION; TARGETS; MODEL; RULE; FISH;

D O I：

10.1016/j.drudis.2024.104022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Active pharmaceutical ingredients (APIs) in the environment, primarily resulting from patient excretion, are of concern because of potential risks to wildlife. This has led to more restrictive regulatory policies. Here, we discuss the 'benign -by -design ' approach, which encourages the development of environmentally friendly APIs that are also safe and ef ficacious for patients. We explore the challenges and opportunities associated with identifying chemical properties that in fluence the environmental impact of APIs. Although a straightforward application of greener properties could hinder the development of new drugs, more nuanced approaches could lead to drugs that bene fit both patients and the environment. We advocate for an enhanced dialogue between research and development (R&D) and environmental scientists and development of a toolbox to incorporate environmental sustainability in drug development.

引用

页数：10

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