Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

被引:17
作者
Chen, Lan [1 ]
Zhang, Yuan [1 ]
Zhang, Yi-Xin [1 ]
Wang, Wei-Lai [1 ]
Sun, De-Mei [1 ]
Li, Peng-Yun [2 ]
Feng, Xue-Song [1 ]
Tan, Yue [3 ]
机构
[1] China Med Univ, Sch Pharm, Shenyang 110122, Peoples R China
[2] Natl Engn Res Ctr Strateg Drugs, Inst Pharmacol & Toxicol Inst, Beijing 100850, Peoples R China
[3] China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang 110022, Peoples R China
关键词
TKIs; Microextraction technique; HRMS methods; Pharmacokinetic studies; Therapeutic drug monitoring; TYROSINE KINASE INHIBITORS; SOLID-PHASE EXTRACTION; PERFORMANCE LIQUID-CHROMATOGRAPHY; RP-HPLC METHOD; TANDEM MASS-SPECTROMETRY; CHRONIC MYELOID-LEUKEMIA; WALLED CARBON NANOTUBE; UPLC-MS/MS METHOD; CLINICAL PHARMACOKINETICS; SIMULTANEOUS QUANTIFICATION;
D O I
10.1016/j.jpha.2023.11.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tyrosine kinase inhibitors (TKIs) have emerged as the first-line small molecule drugs in many cancer therapies, exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling pathways. However, there exists a substantial interindividual variability in the concentrations of certain TKIs and their metabolites, which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments, alongside other potential side effects or adverse reactions. Therefore, an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods, clinical pharmacokinetics, and therapeutic drug monitoring of different TKIs. This paper provides a comprehensive overview of the advancements in pretreatment methods, such as protein precipitation (PPT), liquid-liquid extraction (LLE), solid-phase extraction (SPE), micro-SPE (m-SPE), magnetic SPE (MSPE), and vortex-assisted dispersive SPE (VA-DSPE) achieved since 2017. It also highlights the latest analysis techniques such as newly developed high performance liquid chromatography (HPLC) and high-resolution mass spectrometry (HRMS) methods, capillary electrophoresis (CE), gas chromatography (GC), supercritical fluid chromatography (SFC) procedures, surface plasmon resonance (SPR) assays as well as novel nanoprobes-based biosensing techniques. In addition, a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页数:21
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