Serological Evidence of Zika Virus Infections in Sudan

被引:0
|
作者
Adam, Awadalkareem [1 ,3 ,4 ]
Wenzel, Robert [1 ]
Unger, Elisabeth [1 ,5 ,6 ]
Reiche, Sven [2 ]
Jassoy, Christian [1 ]
机构
[1] Univ Leipzig, Med Ctr, Inst Med Microbiol & Virol, Fac Med, D-04103 Leipzig, Germany
[2] Friedrich Loeffler Inst, Dept Expt Anim Facil & Biorisk Management, D-17493 Greifswald, Germany
[3] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA
[4] Univ Texas Med Branch, Sealy Inst Vaccine Sci, Galveston, TX 77555 USA
[5] Univ Heart & Vasc Ctr Hamburg Eppendorf, Univ Med Ctr Hamburg Eppendorf UKE, Dept Cardiol, Hamburg, Germany
[6] German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Lubeck Kiel, D-20251 Hamburg, Germany
来源
VIRUSES-BASEL | 2024年 / 16卷 / 07期
关键词
Zika virus; Sudan; seroepidemiology; neutralizing antibodies; DENGUE VIRUS;
D O I
10.3390/v16071045
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Little is known about the frequency of Zika virus (ZIKV) infections in Sudan. The aim of this study was to obtain data on the prevalence of ZIKV infections and the immunity of the population in the country. To this end, 198 sera obtained between December 2012 and January 2013 in different regions in Sudan were examined for neutralizing antibodies against ZIKV, dengue virus (DENV), and yellow fever virus (YFV). The sera were non-randomly selected. The neutralization titers were compared with each other and with the WHO 1st International Standard for anti-Asian lineage Zika virus antibody. Twenty-six sera neutralized ZIKV. One-third of these sera had higher neutralization titers against ZIKV than against DENV-2 and -3. Two sera showed higher neutralization titers than the WHO standard for ZIKV antibodies. These data suggest occasional ZIKV infections in Sudan. The low percentage of sera in this cohort that neutralized ZIKV indicates that, in the study period, the population was susceptible to ZIKV infection.
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页数:9
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