Photothermal and ferroptosis synergistic therapy for liver cancer using iron-doped polydopamine nanozymes

被引：10

作者：

Li, Yunchun ^{[1
]}

Qian, Linqun ^{[2
]}

Yang, Zhouping ^{[1
]}

Li, Siyu ^{[3
]}

Wu, Aimin ^{[2
]}

Wang, Xianxiang ^{[1
]}

机构：

[1] Sichuan Agr Univ, Coll Sci, Chengdu 611130, Sichuan, Peoples R China

[2] Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China

[3] State Key Lab Crop Gene Explorat & Utilizat Southw, Chengdu 611130, Sichuan, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2024年 / 239卷

基金：

中国国家自然科学基金;

关键词：

Fe-PDA nanozymes; Ferroptosis; Tumour therapy; Photothermal therapy (PTT); Chemodynamic therapy (CDT);

D O I：

10.1016/j.colsurfb.2024.113911

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

An innovative nanozyme, iron-doped polydopamine (Fe-PDA), which integrates iron ions into a PDA matrix, conferred peroxidase-mimetic activity and achieved a substantial photothermal conversion efficiency of 43.5 %. Fe-PDA mediated the catalysis of H 2 O 2 to produce toxic hydroxyl radicals ( center dot OH), thereby facilitating lipid peroxidation in tumour cells and inducing ferroptosis. Downregulation of solute carrier family 7 no. 11 (SLC7A11) and solute carrier family 3 no. 2 (SLC3A2) in System Xc- resulted in decreased intracellular glutathione (GSH) production and inactivation of the nuclear factor erythroid 2-related factor 2 (NRF2)-glutathione peroxidase 4 (GPX4) pathway, contributing to ferroptosis. Moreover, the application of photothermal therapy (PTT) enhanced the effectiveness of chemodynamic therapy (CDT), accelerating the Fenton reaction for targeted tumour eradication while sparing adjacent non-cancerous tissues. In vivo experiments revealed that Fe-PDA significantly hampered tumour progression in mice, emphasizing the potential of the dual-modality treatment combining CDT and PTT for future clinical oncology applications.

引用

页数：14

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