Photothermal and ferroptosis synergistic therapy for liver cancer using iron-doped polydopamine nanozymes

被引：10
作者：
Li, Yunchun [1 ]
Qian, Linqun [2 ]
Yang, Zhouping [1 ]
Li, Siyu [3 ]
Wu, Aimin [2 ]
Wang, Xianxiang [1 ]
机构：
[1] Sichuan Agr Univ, Coll Sci, Chengdu 611130, Sichuan, Peoples R China
[2] Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China
[3] State Key Lab Crop Gene Explorat & Utilizat Southw, Chengdu 611130, Sichuan, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2024年 / 239卷
基金：
中国国家自然科学基金;
关键词：
Fe-PDA nanozymes; Ferroptosis; Tumour therapy; Photothermal therapy (PTT); Chemodynamic therapy (CDT);
D O I：
10.1016/j.colsurfb.2024.113911
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
An innovative nanozyme, iron-doped polydopamine (Fe-PDA), which integrates iron ions into a PDA matrix, conferred peroxidase-mimetic activity and achieved a substantial photothermal conversion efficiency of 43.5 %. Fe-PDA mediated the catalysis of H 2 O 2 to produce toxic hydroxyl radicals ( center dot OH), thereby facilitating lipid peroxidation in tumour cells and inducing ferroptosis. Downregulation of solute carrier family 7 no. 11 (SLC7A11) and solute carrier family 3 no. 2 (SLC3A2) in System Xc- resulted in decreased intracellular glutathione (GSH) production and inactivation of the nuclear factor erythroid 2-related factor 2 (NRF2)-glutathione peroxidase 4 (GPX4) pathway, contributing to ferroptosis. Moreover, the application of photothermal therapy (PTT) enhanced the effectiveness of chemodynamic therapy (CDT), accelerating the Fenton reaction for targeted tumour eradication while sparing adjacent non-cancerous tissues. In vivo experiments revealed that Fe-PDA significantly hampered tumour progression in mice, emphasizing the potential of the dual-modality treatment combining CDT and PTT for future clinical oncology applications.
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页数：14
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