Plant-derived exosome-like nanovesicles: A novel nanotool for disease therapy

被引：21

作者：

Jin, Ze ^{[1
]}

Na, Jintong ^{[1
]}

Lin, Xia ^{[1
]}

Jiao, Rong ^{[1
]}

Liu, Xiyu ^{[1
]}

Huang, Yong ^{[1
]}

机构：

[1] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & Ther, Guangxi Key Lab Biotargeting Theranost,State Key L, Nanning 530021, Guangxi, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 09期

关键词：

Exosome; Plant -derived exosome-like nanovesicle; Drug delivery; Cancer treatment; Biological effect; EXTRACELLULAR VESICLES; DRUG-DELIVERY; IN-VITRO; CANCER; NANOPARTICLES; ANGIOGENESIS; INHIBIT; GROWTH;

D O I：

10.1016/j.heliyon.2024.e30630

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exosomes are extracellular vesicles comprising bilayer phospholipid membranes and are secreted by eukaryotic cells. They are released via cellular exocytosis, contain DNA, RNA, proteins, and other substances, and participate in various cellular communications between tissues and organs. Since the discovery of exosomes in 1983, animal-derived exosomes have become a research focus for small-molecule drug delivery in biology, medicine, and other fields owing to their good biocompatibility and homing effects. Recent studies have found that plant-derived exosome-like nanovesicles (PELNVs) exhibit certain biological effects, such as anti-inflammatory and antitumor abilities, and have minimal toxic side effects. Because they are rich in active lipid molecules with certain pharmacological effects, PELNVs could be novel carriers for drug delivery. In this review, the biological formation and effects, isolation, and extraction of PELNVs, as well as characteristics of transporting drugs as carriers are summarized to provide new ideas and methods for future research on plant-derived exosome-like nanovesicles.

引用

页数：12

共 93 条

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