The Dawn and Advancement of the Knowledge of the Genetics of Migraine

被引:4
作者
Zalaquett, Nader G. [1 ]
Salameh, Elio [1 ]
Kim, Jonathan M. [2 ]
Ghanbarian, Elham [3 ]
Tawk, Karen [2 ]
Abouzari, Mehdi [2 ]
机构
[1] Amer Univ Beirut, Fac Med, Beirut 1107, Lebanon
[2] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Dept Neurol, Irvine, CA 92617 USA
关键词
migraine; migraine with aura (MA); migraine without aura (MO); familial hemiplegic migraine (FHM); genetics; FAMILIAL HEMIPLEGIC MIGRAINE; GENOME-WIDE ASSOCIATION; O-METHYLTRANSFERASE GENE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; MTHFR C677T POLYMORPHISM; RECEPTOR MESSENGER-RNA; CENTRAL-NERVOUS-SYSTEM; SMALL-VESSEL DISEASE; SPREADING DEPRESSION; SUSCEPTIBILITY LOCUS;
D O I
10.3390/jcm13092701
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Migraine is a prevalent episodic brain disorder known for recurrent attacks of unilateral headaches, accompanied by complaints of photophobia, phonophobia, nausea, and vomiting. Two main categories of migraine are migraine with aura (MA) and migraine without aura (MO). Main body: Early twin and population studies have shown a genetic basis for these disorders, and efforts have been invested since to discern the genes involved. Many techniques, including candidate-gene association studies, loci linkage studies, genome-wide association, and transcription studies, have been used for this goal. As a result, several genes were pinned with concurrent and conflicting data among studies. It is important to understand the evolution of techniques and their findings. Conclusions: This review provides a chronological understanding of the different techniques used from the dawn of migraine genetic investigations and the genes linked with the migraine subtypes.
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页数:30
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