Effect of Remimazolam on Induction and Maintenance of General Anesthesia in Kidney Transplant Patients

被引:1
作者
Chen, Lini [1 ]
Qin, Weiyong [1 ]
Wu, Jiangdong [1 ]
Zhao, Guilin [1 ]
Jiang, Xiaoqing [1 ]
Li, Minghui [1 ]
Huang, Zijin [1 ]
Du, Xueke [1 ]
机构
[1] Guangxi Med Univ, Dept Gastroenterol, Affiliated Hosp 2, 166 Daxue East Rd, Nanning 530007, Guangxi, Peoples R China
来源
INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2024年 / 17卷
关键词
remimazolam; propofol; general anesthesia; kidney transplant; PROPOFOL;
D O I
10.2147/IJGM.S464530
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: This study aims to evaluate the effect of remimazolam on induction and maintenance of general anesthesia in kidney transplant patients. Methods: 120 patients undergoing kidney transplant were divided into two groups: Propofol group (Group P) and Remimazolam group (Group R). Anesthesia induction: remimazolam had injected IV at a dose of 0.15-0.35 mg/kg in Group R, while propofol had injected IV at a dose of 2.0-2.5 mg/kg in Group P. Anesthesia maintenance: remimazolam was injected IV at a dose of 0.3-1.0 mg center dot kg(- 1)center dot h(-1) and propofol was injected IV at a dose of 1-12 mg center dot kg(- 1)center dot h(-1) in Group R, propofol was injected IV at a dose of 3-12 mg center dot kg(- 1)center dot h(-1) in Group P. All patients have the same remaining anesthesia durgs. Results: Compared with Group P, in Group R the time of disappearance of the eyelash reflex and the time to drop to 60 in BIS was longer (P < 0.05), the time of awakening was shorted (P < 0.05), the MAP of T-6 was fluctuated less (P < 0.05), the incidence of hypotension and injection pain during induction was reduced (P < 0.001), the incidence of intraoperative bradycardia during operation was reduced (P < 0.05), the dosages of sedatives drug during maintenance was reduced (P < 0.05). There was no statistically significant difference in postoperative renal function between the two groups of patients (P > 0.05). Conclusion: Remimazolam can be safely and effectively used for the induction and maintenance of general anesthesia in kidney transplant patients.
引用
收藏
页码:2455 / 2463
页数:9
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