Three-Component Gold(I)-Catalyzed Alkoxyvinylation

被引：1
|
作者：
Hammarback, L. Anders [1 ]
Medina-Gil, Tania [1 ,2 ]
Sadurni, Anna [1 ]
Echavarren, Antonio M. [1 ,2 ]
机构：
[1] Barcelona Inst Sci & Technol BIST, Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain
[2] Univ Rovira & Virgili URV, Dept Quim Organ & Anal, Tarragona 43007, Spain
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 30期
基金：
欧洲研究理事会;
关键词：
INTERMOLECULAR 2+2 CYCLOADDITION; GOLD; ACETYLENE;
D O I：
10.1021/acs.orglett.4c02102
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Acetylene has been underexploited despite being a highly valuable feedstock for chemical synthesis. We have developed the first true gold(I)-catalyzed intermolecular three-component reaction between acetylene, alkenes, and alcohols to afford beta-vinyl hemiaminal scaffolds from N-vinyl amides. Unusual biscyclopropyl and 3-vinyl N-heterocyclic scaffolds were obtained through the incorporation of a second N-vinyl unit or tethered alkene into the starting material.
引用
收藏
页码：6375 / 6379
页数：5
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