Nitric Oxide: The Missing Factor in COVID-19 Severity?

被引：16
作者：
Nikolaidis, Alexandros [1 ]
Kramer, Ron [2 ]
Ostojic, Sergej [3 ]
机构：
[1] NKG Pharmaceut, Signal Hill, CA 90755 USA
[2] ThermoLife Int, Phoenix, AZ 85048 USA
[3] Univ Novi Sad, Fac Sport & PE, Appl Bioenerget Lab, Novi Sad 21102, Serbia
来源：
MEDICAL SCIENCES | 2022年 / 10卷 / 01期
关键词：
COVID-19; SARS-CoV-2; nitric oxide; NO; comorbidities; etiology; ARGININE METHYL-ESTER; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; INORGANIC NITRATE; OXIDATIVE STRESS; NITROGEN-DIOXIDE; DIETARY NITRATE; IN-VITRO; OBESITY; EXPRESSION;
D O I：
10.3390/medsci10010003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coronavirus disease 2019 (COVID-19) is a contagious respiratory and vascular disease that continues to spread among people around the world, mutating into new strains with increased transmission rates, such as the delta variant. The scientific community is struggling to discover the link between negative COVID-19 outcomes in patients with preexisting conditions, as well as identify the cause of the negative clinical patient outcomes (patients who need medical attention, including hospitalization) in what seems like a widespread range of COVID-19 symptoms that manifest atypically to any preexisting respiratory tract infectious diseases known so far. Having successfully developed a nutritional formulation intervention based on nitrate, a nitric oxide precursor, the authors hypothesis is that both the comorbidities associated with negative clinical patient outcomes and symptoms associated with COVID-19 sickness are linked to the depletion of a simple molecule: nitric oxide.
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页数：15
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