Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System

被引：9

作者：

Raisi-Estabragh, Zahra ^{[1
,2
]}

Szabo, Liliana ^{[1
,2
,3
]}

Schuermans, Art ^{[4
,5
,6
]}

Salih, Ahmed M. ^{[1
,7
,8
]}

Chin, Calvin W. L. ^{[9
,10
]}

Vago, Hajnalka ^{[3
]}

Altmann, Andre ^{[11
]}

Ng, Fu Siong ^{[12
]}

Garg, Pankaj ^{[13
,14
]}

Pavanello, Sofia ^{[15
,16
,17
]}

Marwick, Thomas H. ^{[18
]}

Petersen, Steffen E. ^{[1
,2
,19
]}

机构：

[1] Queen Mary Univ London, William Harvey Res Inst, NIHR Barts Biomed Res Ctr, Charterhouse Sq, London EC1M 6BQ, England

[2] St Bartholomews Hosp, Barts Heart Ctr, Barts Hlth NHS Trust, London, England

[3] Semmelweis Univ, Heart & Vasc Ctr, Budapest, Hungary

[4] Katholieke Univ Leuven, Fac Med, Leuven, Belgium

[5] Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA

[6] Harvard Med Sch, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA USA

[7] Univ Leicester, Dept Populat Hlth Sci, Leicester, England

[8] Univ Zakho, Fac Sci, Dept Comp Sci, Zakho, Kurdistan, Iraq

[9] Natl Heart Ctr Singapore, Dept Cardiol, Singapore, Singapore

[10] Duke Natl Univ Singapore Med Sch, Cardiovasc Acad Clin Programme, Singapore, Singapore

[11] UCL, Ctr Med Image Comp, Dept Med Phys & Biomed Engn, London, England

[12] Imperial Coll London, Natl Heart & Lung Inst, London, England

[13] Univ East Anglia, Norwich Med Sch, Norwich, England

[14] Norfolk & Norwich Univ Hosp NHS Fdn Trust, Norwich, England

[15] Univ Padua, Dept Cardiothoraco Vasc Sci & Publ Hlth, Occupat Med, Padua, Italy

[16] Padua Hosp, Occupat Med Unit, Padua, Italy

[17] Univ Padua, Univ Ctr Space Studies & Act Giuseppe Colombo CISA, Padua, Italy

[18] Baker Heart & Diabet Inst, Melbourne, Australia

[19] Hlth Data Res UK, London, England

来源：

JACC-CARDIOVASCULAR IMAGING | 2024年 / 17卷 / 05期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

biological heart age; cardiac computed tomography; cardiac magnetic resonance; echocardiography; healthy aging; molecular markers; multimodality cardiovascular imaging; CORONARY-HEART-DISEASE; LEFT-VENTRICULAR MASS; CLONAL HEMATOPOIESIS; ARTERIAL STIFFNESS; EJECTION FRACTION; SINOATRIAL NODE; LONGITUDINAL TRACKING; AORTIC-STENOSIS; TELOMERE LENGTH; WAVE REFLECTION;

D O I：

10.1016/j.jcmg.2024.03.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Population aging is one of the most important demographic transformations of our time. Increasing the "health span "- the proportion of life spent in good health -is a global priority. Biological aging comprises molecular and cellular modi fications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age -related illnesses. Cardiovascular disease is a major cause of ill health and premature death in older people. The rate at which biological aging occurs varies across individuals of the same age and is in fluenced by a wide range of genetic and environmental exposures. The authors review the hallmarks of biological cardiovascular aging and their capture using imaging and other noninvasive techniques and examine how this information may be used to understand aging trajectories, with the aim of guiding individual- and population -level interventions to promote healthy aging. (J Am Coll Cardiol Img 2024;17:533 -551) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).

引用

页码：533 / 551

页数：19

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