Re-exploration of immunotherapy targeting EMT of hepatocellular carcinoma: Starting from the NF-κB pathway

被引:4
作者
Wang, Shuang [1 ]
He, Yan [2 ]
Wang, Jun [1 ]
Luo, En [1 ]
机构
[1] Chengdu Fifth Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Chengdu 611130, Sichuan, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu 611137, Sichuan, Peoples R China
关键词
EMT; NF-kappa B; Hepatocellular carcinoma; MicroRNAs; EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTOR SNAIL; PROMOTES METASTASIS; SIGNALING PATHWAY; UP-REGULATION; RECEPTOR; CANCER; CELL; EXPRESSION; INVASION;
D O I
10.1016/j.biopha.2024.116566
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Hepatocellular carcinoma (HCC) is the fifth most common malignancies worldwide, and its high morbidity and mortality have brought a heavy burden to the global public health system. Due to the concealment of its onset, the limitation of treatment, the acquisition of multi -drug resistance and radiation resistance, the treatment of HCC cannot achieve satisfactory results. Epithelial mesenchymal transformation (EMT) is a key process that induces progression, distant metastasis, and therapeutic resistance to a variety of malignant tumors, including HCC. Therefore, targeting EMT has become a promising tumor immunotherapy method for HCC. The NF -KB pathway is a key regulatory pathway for EMT. Targeting this pathway has shown potential to inhibit HCC infiltration, invasion, distant metastasis, and therapeutic resistance. At present, there are still some controversies about this pathway and new ideas of combined therapy, which need to be further explored. This article reviews the progress of immunotherapy in improving EMT development in HCC cells by exploring the mechanism of regulating EMT.
引用
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页数:12
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