Recent advances in the green synthesis of indole and its derivatives using microwave irradiation and the role of indole moiety in cancer

被引：1
作者：
Almalki, Faisal A. [1 ]
Baryyan, Alaa O. [1 ]
机构：
[1] Umm Al Qura Univ, Fac Pharm, Dept Pharmaceut Sci, Mecca 21955, Saudi Arabia
来源：
GREEN CHEMISTRY LETTERS AND REVIEWS | 2024年 / 17卷 / 01期
关键词：
Indole; microwave irradiation; catalyst; green chemistry; yield; MULTIFUNCTIONAL DRUGS SYNTHESIS; ANTICANCER AGENTS; MOLECULAR DOCKING; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; ACRYLAMIDE DERIVATIVES; ASSISTED SYNTHESIS; TOPOISOMERASE-II; DESIGN; ANTIOXIDANT;
D O I：
10.1080/17518253.2024.2362925
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Indole moiety is widely present in several natural bioactive products and medicinally important compounds. It is an essential scaffold for the development of novel leads. Nowadays, the synthesis of indoles by conventional methods is replaced with greener ones. The dynamic growth in green organic synthetic approaches for different heterocyclic scaffolds has markedly contributed to the field of medicinal chemistry over the last few decades. This review article compiled the last seven years' results in the green synthesis of indole and its derivatives using microwave irradiations from 2018 to 2024. Microwave (MW) assisted reactions are very rapid, environment-friendly, proficient, and convenient methodologies for the synthesis of organic compounds. This review contains synthetic procedures, reaction conditions, and greener features in synthesizing indole and its derivatives. This review article aims to promote greener synthesis methods and guide the researchers to design, develop, and synthesize indole-based derivatives using a microwave irradiation technique. This article also discusses the anticancer potential of indole-containing compounds reported in recent literature. [GRAPHICS] .
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页数：33
相关论文
共 125 条
[1]  
Abd El-Lateef H.M., 2024, Bull. Chem. Soc. Ethiop, V38, P1077
[2]  
Abdelazeem N., C-Myc Il-6
[3]  
Al-Ajely H.M., 2022, MINAR International Journal of Applied Sciences and Technology, V4, P514
[4]   Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity [J].
Al-Hussain, Sami A. ;
Farghaly, Thoraya A. ;
Zaki, Magdi E. A. ;
Abdulwahab, Hanan G. ;
Al-Qurashi, Nadia T. ;
Muhammad, Zeinab A. .
BIOORGANIC CHEMISTRY, 2020, 105
[5]   Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors [J].
Al-Warhi, Tarfah ;
El Kerdawy, Ahmed M. ;
Aljaeed, Nada ;
Ismael, Omnia E. ;
Ayyad, Rezk R. ;
Eldehna, Wagdy M. ;
Abdel-Aziz, Hatem A. ;
Al-Ansary, Ghada H. .
MOLECULES, 2020, 25 (09)
[6]   Microwave Irradiation: Alternative Heating Process for the Synthesis of Biologically Applicable Chromones, Quinolones, and Their Precursors [J].
Albuquerque, Helio M. T. ;
Pinto, Diana C. G. A. ;
Silva, Artur M. S. .
MOLECULES, 2021, 26 (20)
[7]   Design, Synthesis, and Potent Anticancer Activity of Novel Indole-Based Bcl-2 Inhibitors [J].
Almehdi, Ahmed M. ;
Soliman, Sameh S. M. ;
El-Shorbagi, Abdel-Nasser A. ;
Westwell, Andrew D. ;
Hamdy, Rania .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
[8]   Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity [J].
Ammar, Yousry A. ;
El-Sharief, Ahmed M. Sh ;
Belal, Amany ;
Abbas, Samir Y. ;
Mohamed, Yehia A. ;
Mehany, Ahmed B. M. ;
Ragab, Ahmed .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 156 :918-932
[9]   Green Chemistry: Principles and Practice [J].
Anastas, Paul ;
Eghbali, Nicolas .
CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) :301-312
[10]   Microwave assisted one-pot, three component synthesis of Indolyl-5H- chromeno[2,3-b] pyridinederivatives [J].
Avula, Raghavendar ;
Babu, H. Sharath ;
Venkatanarayana, Muvvala .
CHEMICAL DATA COLLECTIONS, 2022, 38
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