Antimicrobial resistance (AMR) is one of the most critical threats to global public health in the 21st century, causing a large number of deaths every year in both high-income and low- and middle-income countries. Vaccines and monoclonal antibodies can be exploited to prevent and treat diseases caused by AMR pathogens, thereby reducing antibiotic use and decreasing selective pressure that favors the emergence of resistant strains. Here, differences in the mechanism of action and resistance of vaccines and monoclonal antibodies compared to antibiotics are discussed. The state of the art for vaccine technologies and monoclonal antibodies are reviewed, with a particular focus on approaches validated in clinical studies. By underscoring the scope and limitations of the different emerging technologies, this review points out the complementary of vaccines and monoclonal antibodies in fighting AMR. Gaps in antigen discovery for some pathogens, as well as challenges associated with the clinical development of these therapies against AMR pathogens, are highlighted.
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Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi ArabiaShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Alotaibi, Ghallab
Khan, Kanwal
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Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi, PakistanShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Khan, Kanwal
Mouslem, Abdulaziz K. Al
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King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi ArabiaShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Mouslem, Abdulaziz K. Al
Khan, Saeed Ahmad
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Dept Pharm KUST, Kohat 26000, KP, PakistanShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Khan, Saeed Ahmad
Abbas, Muhammad Naseer
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Dept Pharm KUST, Kohat 26000, KP, Pakistan
Univ Karachi, Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, PakistanShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
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Ramon y Cajal Univ Hosp, Ramon y Cajal Inst Hlth Res IRYCIS, Dept Microbiol, Madrid, SpainRamon y Cajal Univ Hosp, Ramon y Cajal Inst Hlth Res IRYCIS, Dept Microbiol, Madrid, Spain
Baquero, Fernando
Levin, Bruce R.
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Emory Univ, Dept Biol, Atlanta, GA 30322 USA
Emory Univ, Antibiot Resistance Ctr, Atlanta, GA 30322 USARamon y Cajal Univ Hosp, Ramon y Cajal Inst Hlth Res IRYCIS, Dept Microbiol, Madrid, Spain
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Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Bernardino, Paola Nol
Bhattacharya, Mohini
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Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
CU Anschutz Med Campus, Dept Immunol, Aurora, CO USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Bhattacharya, Mohini
Chen, Xinhai
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Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Inst Infect Dis, Shenzhen Bay Lab, Shenzhen 518132, Peoples R ChinaUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Chen, Xinhai
Jenkins, Julia
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Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Royal United Hosp Bath NHS Fdn Trust, Bath, EnglandUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Jenkins, Julia
Missiakas, Dominique
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Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Missiakas, Dominique
Thammavongsa, Vilasack
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Sensaphon Hearing Conservat Inc, 660 N Milwaukee Ave, Chicago, IL 60642 USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
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Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi ArabiaShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Alotaibi, Ghallab
Khan, Kanwal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi, PakistanShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Khan, Kanwal
Mouslem, Abdulaziz K. Al
论文数: 0引用数: 0
h-index: 0
机构:
King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi ArabiaShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Mouslem, Abdulaziz K. Al
Khan, Saeed Ahmad
论文数: 0引用数: 0
h-index: 0
机构:
Dept Pharm KUST, Kohat 26000, KP, PakistanShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
Khan, Saeed Ahmad
Abbas, Muhammad Naseer
论文数: 0引用数: 0
h-index: 0
机构:
Dept Pharm KUST, Kohat 26000, KP, Pakistan
Univ Karachi, Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, PakistanShaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Shaqra, Saudi Arabia
机构:
Ramon y Cajal Univ Hosp, Ramon y Cajal Inst Hlth Res IRYCIS, Dept Microbiol, Madrid, SpainRamon y Cajal Univ Hosp, Ramon y Cajal Inst Hlth Res IRYCIS, Dept Microbiol, Madrid, Spain
Baquero, Fernando
Levin, Bruce R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA
Emory Univ, Antibiot Resistance Ctr, Atlanta, GA 30322 USARamon y Cajal Univ Hosp, Ramon y Cajal Inst Hlth Res IRYCIS, Dept Microbiol, Madrid, Spain
机构:
Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Bernardino, Paola Nol
Bhattacharya, Mohini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
CU Anschutz Med Campus, Dept Immunol, Aurora, CO USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Bhattacharya, Mohini
Chen, Xinhai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Inst Infect Dis, Shenzhen Bay Lab, Shenzhen 518132, Peoples R ChinaUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Chen, Xinhai
Jenkins, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Royal United Hosp Bath NHS Fdn Trust, Bath, EnglandUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Jenkins, Julia
Missiakas, Dominique
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA
Missiakas, Dominique
Thammavongsa, Vilasack
论文数: 0引用数: 0
h-index: 0
机构:
Sensaphon Hearing Conservat Inc, 660 N Milwaukee Ave, Chicago, IL 60642 USAUniv Chicago, Dept Microbiol, Howard Taylor Ricketts Lab, Lemont, IL 60439 USA