Updates on the Renin-Angiotensin-Aldosterone System and the Cardiovascular Continuum

被引：1
作者：
Pop, Dana [1 ,2 ]
Dadarlat-Pop, Alexandra [1 ,3 ]
Tomoaia, Raluca [1 ,2 ]
Zdrenghea, Dumitru [1 ]
Caloian, Bogdan [1 ,2 ]
机构：
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Internal Med 4, Cluj Napoca 400347, Romania
[2] Rehabil Hosp, Cardiol Dept, Cluj Napoca 400012, Romania
[3] Heart Inst N Stancioiu, Cardiol Dept, Cluj Napoca 400001, Romania
来源：
BIOMEDICINES | 2024年 / 12卷 / 07期
关键词：
renin-angiotensin-aldosterone system; cardiovascular risk factors; stroke; heart failure; atrial fibrillation; CONVERTING-ENZYME-INHIBITORS; LEFT-VENTRICULAR DYSFUNCTION; CORONARY-ARTERY-DISEASE; HIGH-RISK PATIENTS; HEART-FAILURE; ATRIAL-FIBRILLATION; MYOCARDIAL-INFARCTION; RECEPTOR; THERAPY; PERINDOPRIL;
D O I：
10.3390/biomedicines12071582
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cardiovascular continuum describes how several cardiovascular risk factors contribute to the development of atherothrombosis, ischemic heart disease, and peripheral arteriopathy, leading to cardiac and renal failure and ultimately death. Due to its multiple valences, the renin-angiotensin-aldosterone system plays an important role in all stages of the cardiovascular continuum, starting from a cluster of cardiovascular risk factors, and continuing with the development of atherosclerosis thorough various mechanisms, and culminating with heart failure. Therefore, this article aims to analyze how certain components of the renin-angiotensin-aldosterone system (converting enzymes, angiotensin, angiotensin receptors, and aldosterone) are involved in the underlying pathophysiology of the cardiovascular continuum and the possible arrest of its progression.
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页数：12
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