Updates on the Renin-Angiotensin-Aldosterone System and the Cardiovascular Continuum

被引：1
作者：
Pop, Dana [1 ,2 ]
Dadarlat-Pop, Alexandra [1 ,3 ]
Tomoaia, Raluca [1 ,2 ]
Zdrenghea, Dumitru [1 ]
Caloian, Bogdan [1 ,2 ]
机构：
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Internal Med 4, Cluj Napoca 400347, Romania
[2] Rehabil Hosp, Cardiol Dept, Cluj Napoca 400012, Romania
[3] Heart Inst N Stancioiu, Cardiol Dept, Cluj Napoca 400001, Romania
来源：
BIOMEDICINES | 2024年 / 12卷 / 07期
关键词：
renin-angiotensin-aldosterone system; cardiovascular risk factors; stroke; heart failure; atrial fibrillation; CONVERTING-ENZYME-INHIBITORS; LEFT-VENTRICULAR DYSFUNCTION; CORONARY-ARTERY-DISEASE; HIGH-RISK PATIENTS; HEART-FAILURE; ATRIAL-FIBRILLATION; MYOCARDIAL-INFARCTION; RECEPTOR; THERAPY; PERINDOPRIL;
D O I：
10.3390/biomedicines12071582
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cardiovascular continuum describes how several cardiovascular risk factors contribute to the development of atherothrombosis, ischemic heart disease, and peripheral arteriopathy, leading to cardiac and renal failure and ultimately death. Due to its multiple valences, the renin-angiotensin-aldosterone system plays an important role in all stages of the cardiovascular continuum, starting from a cluster of cardiovascular risk factors, and continuing with the development of atherosclerosis thorough various mechanisms, and culminating with heart failure. Therefore, this article aims to analyze how certain components of the renin-angiotensin-aldosterone system (converting enzymes, angiotensin, angiotensin receptors, and aldosterone) are involved in the underlying pathophysiology of the cardiovascular continuum and the possible arrest of its progression.
引用
收藏
页数：12
相关论文
共 77 条
  • [1] The Pivotal Role of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers in Hypertension Management and Cardiovascular and Renal Protection: A Critical Appraisal and Comparison of International Guidelines
    Alcocer, Luis Antonio
    Bryce, Alfonso
    Brasil, David De Padua
    Lara, Joffre
    Cortes, Javier Moreno
    Quesada, Daniel
    Rodriguez, Pablo
    [J]. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2023, 23 (06) : 663 - 682
  • [2] THE EFFECT OF THE ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR ZOFENOPRIL ON MORTALITY AND MORBIDITY AFTER ANTERIOR MYOCARDIAL-INFARCTION
    AMBROSIONI, E
    BORGHI, C
    MAGNANI, B
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (02) : 80 - 85
  • [3] Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery
    Benicky, Julius
    Sanchez-Lemus, Enrique
    Pavel, Jaroslav
    Saavedra, Juan M.
    [J]. CELLULAR AND MOLECULAR NEUROBIOLOGY, 2009, 29 (6-7) : 781 - 792
  • [4] Benigni A, 2001, J AM SOC NEPHROL, V12, P941, DOI 10.1681/ASN.V125941
  • [5] The renin-angiotensin-aldosterone system and the kidney: Effects on kidney disease
    Brewster, UC
    Perazella, MA
    [J]. AMERICAN JOURNAL OF MEDICINE, 2004, 116 (04) : 263 - 272
  • [6] ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT
    Ceconi, Claudio
    Fox, Kim M.
    Remme, William J.
    Simoons, Marteen L.
    Bertrand, Michael
    Parrinello, Giovanni
    Kluft, Cornelius
    Blann, Andrew
    Cokkinos, Dennis
    Ferrari, Roberto
    [J]. CARDIOVASCULAR RESEARCH, 2007, 73 (01) : 237 - 246
  • [7] ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis: Results from the PERTINENT study
    Ceconi, Claudio
    Fox, Kim M.
    Remme, William J.
    Simoons, Maarten L.
    Deckers, Jaap W.
    Bertrand, Michel
    Parrinello, Giovanni
    Kluft, Cornelius
    Blann, Andrew
    Cokkinos, Dennis
    Ferrari, Roberto
    [J]. ATHEROSCLEROSIS, 2009, 204 (01) : 273 - 275
  • [8] Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes
    Chaturvedi, N
    Sjolie, AK
    Stephenson, JM
    Abrahamian, H
    Keipes, M
    Castellarin, A
    Rogulja-Pepeonik, Z
    Fuller, JH
    [J]. LANCET, 1998, 351 (9095) : 28 - 31
  • [9] Effects of RAAS Blockers on Atrial Fibrillation Prophylaxis: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Chaugai, Sandip
    Meng, Wen Yeng
    Sepehry, Amir Ali
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2016, 21 (04) : 388 - 404
  • [10] Interaction of oxidized low-density lipoprotein and the renin-angiotensin system in coronary artery disease
    Chen, Jiawei
    Mehta, Jawahar L.
    [J]. CURRENT HYPERTENSION REPORTS, 2006, 8 (02) : 139 - 143
12345678