OPTIMIZATION OF THE SYNTHESIS OF FUNCTIONALLY SUBSTITUTED TRIAZOLES

Triazole derivatives are used as biologically active substances with various effects; they have antibacterial, neuroleptic, hypotensive and antispasmodic activity, and stimulate cardiac activity. They are used as ligands in organometallic complexes, as optical brighteners, intermediates for the production of plasticizers, corrosion inhibitors, herbicides, catalysts. The chemistry of heterocyclic compounds is one of the important branches of organic chemistry. Heterocyclic compounds are widely distributed in living nature and play a key role in the metabolism of living organisms. Among the variety of heterocyclic systems that are currently being intensively studied there are still quite a lot of interesting and little -studied classes of compounds, which include bigetaryls. Heterocyclic compounds are the most numerous and a class of organics that is diverse in its set of ancestral structures compounds. However, most of the widely used drugs are synthetic derivatives of various heterocycles, and primarily these include drugs with anticancer, analeptic, analgesic or cardiovascular effects. A convenient method for obtaining functionally substituted triazoles is the Huisgen reaction - C -C cycloaddition of organic azides to activated substrates. The reaction was carried out in dioxane, tetrahydrofuran environment. Better results were obtained in DMSO medium at 25 o C for 3 h, yielding 85% of the target product. Furthermore, various conditions were studied for the enolate-azide cycloaddition reaction with the selective formation of 1-aryl(hetaryl)-4,5-substituted 1,2,3-triazoles. The optimal conditions for the bromination reaction of 1-(5-methyl-1-phenyl-1,2,3triazol-4-yl)ethane have been studied to obtain alpha -monobromosubstituted ketone