AI-enabled organoids: Construction, analysis, and application

被引：77

作者：

Bai, Long

Wu, Yan ^{[1
,2
]}

Li, Guangfeng ^{[2
,3
,5
]}

Zhang, Wencai ^{[4
]}

Zhang, Hao ^{[1
,2
,3
]}

Su, Jiacan ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai 200092, Peoples R China

[2] Shanghai Univ, Inst Translat Med, Organoid Res Ctr, Shanghai 200444, Peoples R China

[3] Shanghai Univ, Natl Ctr Translat Med Shanghai SHU Branch, Shanghai 200444, Peoples R China

[4] Jinan Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou 510632, Peoples R China

[5] Shanghai Zhongye Hosp, Dept Orthoped, Shanghai 201941, Peoples R China

来源：

BIOACTIVE MATERIALS | 2024年 / 31卷

基金：

中国国家自然科学基金;

关键词：

Organoids; Artificial intelligence; Construction strategy; Data analysis; Preclinical evaluation and application; PLURIPOTENT STEM-CELLS; GRAPH NEURAL-NETWORKS; ARTIFICIAL-INTELLIGENCE; CEREBRAL ORGANOIDS; LOGISTIC-REGRESSION; OMICS DATA; DISEASE; GENERATION; MODEL; HYDROGEL;

D O I：

10.1016/j.bioactmat.2023.09.005

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Organoids, miniature and simplified in vitro model systems that mimic the structure and function of organs, have attracted considerable interest due to their promising applications in disease modeling, drug screening, personalized medicine, and tissue engineering. Despite the substantial success in cultivating physiologically relevant organoids, challenges remain concerning the complexities of their assembly and the difficulties associated with data analysis. The advent of AI-Enabled Organoids, which interfaces with artificial intelligence (AI), holds the potential to revolutionize the field by offering novel insights and methodologies that can expedite the development and clinical application of organoids. This review succinctly delineates the fundamental concepts and mechanisms underlying AI-Enabled Organoids, summarizing the prospective applications on rapid screening of construction strategies, cost-effective extraction of multiscale image features, streamlined analysis of multi-omics data, and precise preclinical evaluation and application. We also explore the challenges and limitations of interfacing organoids with AI, and discuss the future direction of the field. Taken together, the AI-Enabled Organoids hold significant promise for advancing our understanding of organ development and disease progression, ultimately laying the groundwork for clinical application.

引用

页码：525 / 548

页数：24

共 176 条

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