The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

被引:28
作者
Andoh, Vivian [1 ]
Ocansey, Dickson Kofi Wiredu [2 ,3 ]
Naveed, Hassan [1 ]
Wang, Naijian [4 ]
Chen, Liang [1 ]
Chen, Keping [1 ]
Mao, Fei [2 ]
机构
[1] Jiangsu Univ, Sch Life Sci, Zhenjiang, Peoples R China
[2] Jiangsu Univ, Lianyungang Clin Coll, Dept Lab Med, Lianyungang 222006, Jiangsu, Peoples R China
[3] Univ Cape Coast, Directorate Univ Hlth Serv, CC0959347, Cape Coast, Ghana
[4] Jiangsu Univ, Sch Med, Key Lab Med Sci & Lab Med Jiangsu Prov, Zhenjiang, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
nanocomposites; cancer; diagnosis; therapy; nanoparticles; theranostic; THERAPY CURRENT PROGRESS; METAL-ORGANIC FRAMEWORK; REDUCED GRAPHENE OXIDE; DRUG-DELIVERY SYSTEMS; BREAST-CANCER; CERAMIC NANOCOMPOSITES; PHOTODYNAMIC THERAPY; GOLD NANOPARTICLES; CO-DELIVERY; NANOMATERIALS;
D O I
10.2147/IJN.S471360
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The relentless pursuit of effective cancer diagnosis and treatment strategies has led to the rapidly expanding field of nanotechnology, with a specific focus on nanocomposites. Nanocomposites, a combination of nanomaterials with diverse properties, have emerged as versatile tools in oncology, offering multifunctional platforms for targeted delivery, imaging, and therapeutic interventions. Nanocomposites exhibit great potential for early detection and accurate imaging in cancer diagnosis. Integrating various imaging modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), and fluorescence imaging, into nanocomposites enables the development of contrast agents with enhanced sensitivity and specificity. Moreover, functionalizing nanocomposites with targeting ligands ensures selective accumulation in tumor tissues, facilitating precise imaging and diagnostic accuracy. On the therapeutic front, nanocomposites have revolutionized cancer treatment by overcoming traditional challenges associated with drug delivery. The controlled release of therapeutic agents from nanocomposite carriers enhances drug bioavailability, reduces systemic toxicity, and improves overall treatment efficacy. Additionally, the integration of stimuli-responsive components within nanocomposites enables site-specific drug release triggered by the unique microenvironment of the tumor. Despite the remarkable progress in the field, challenges such as biocompatibility, scalability, and long-term safety profiles remain. This article provides a comprehensive overview of recent developments, challenges, and prospects, emphasizing the transformative potential of nanocomposites in revolutionizing the landscape of cancer diagnostics and therapeutics. In Conclusion, integrating nanocomposites in cancer diagnosis and treatment heralds a new era for precision medicine.
引用
收藏
页码:6099 / 6126
页数:28
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