The effect of oral pregabalin on the minimum alveolar concentration of isoflurane in cats

被引：0
作者：
Luo, Luting [1 ]
Chen, Hangbin [1 ]
Zhu, Yunjie [1 ]
Wu, Yue [1 ]
Guo, Weibin [2 ]
Yang, Zhen [3 ]
Li, Meng [1 ,4 ]
机构：
[1] Nanjing Agr Univ, Coll Vet Med, Dept Vet Clin Sci, Nanjing, Jiangsu, Peoples R China
[2] Ainuo Baisi Anim Hosp, Guangzhou, Guangdong, Peoples R China
[3] Nanjing Agr Univ, Coll Vet Med, Dept Preventat Vet Med, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Agr Univ, Vet Teaching Hosp, Nanjing, Jiangsu, Peoples R China
来源：
VETERINARY ANAESTHESIA AND ANALGESIA | 2024年 / 51卷 / 04期
关键词：
anesthesia; cat; iso fl urane; minimum alveolar concentration; pregabalin; GABAPENTIN; PHARMACOKINETICS; SEVOFLURANE; MORPHINE; PLASMA; HPLC; PAIN;
D O I：
10.1016/j.vaa.2024.04.007
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Methods Cats were randomly assigned to three oral doses of pregabalin (low dose: 2.5 mg kg-1, medium dose: 5 mg kg-1, high dose: 10 mg kg-1) or placebo 2 hours before MACISO determination, with the multiple treatments administered with a minimum 7 day washout period. Anesthesia was induced and maintained with isoflurane in oxygen until endotracheal intubation was achieved, and maintained with isoflurane with volume-controlled ventilation. MACISO was
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页码：391 / 398
页数：8
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