Weight-Reducing Dietary Intervention Increases the Ability of Hyperinsulinemia to Suppress Serum Ghrelin Concentration in Individuals with Obesity

被引：0

作者：

Karczewska-Kupczewska, Monika ^{[1
]}

Stefanowicz, Magdalena ^{[2
]}

Nikolajuk, Agnieszka ^{[3
]}

Straczkowski, Marek ^{[3
]}

机构：

[1] Med Univ Bialystok, Dept Internal Med & Metab Dis, Bialystok, Poland

[2] Med Univ Bialystok, Dept Metab Dis, Bialystok, Poland

[3] Polish Acad Sci, Inst Anim Reprod & Food Res, Dept Prophylaxis Metab Dis, Olsztyn, Poland

来源：

JOURNAL OF NUTRITION | 2024年 / 154卷 / 05期

关键词：

serum ghrelin; obesity; insulin; insulin sensitivity; weight loss; PLASMA GHRELIN; INSULIN SENSITIVITY; GENE-EXPRESSION; OVERWEIGHT; APPETITE; PEPTIDE; WOMEN; MEAL;

D O I：

10.1016/j.tjnut.2023.12.043

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Ghrelin is an orexigenic peptide secreted mainly by the stomach. Serum ghrelin concentrations are suppressed after a meal, probably due to insulin release. Individuals with obesity are characterized by a lower fasting serum ghrelin and a lower ghrelin decrease after a meal. The effect of weight loss on the ability of insulin to suppress serum ghrelin concentration remains unknown. Objective: The aim of the present study was to analyze the effect of weight -reducing dietary intervention on the ability of hyperinsulinemia to suppress serum ghrelin concentration in young individuals with uncomplicated obesity. Methods: We examined 38 individuals with marked overweight or obesity, who underwent a 12 -wk dietary intervention program. Serum ghrelin concentration was measured before and after a 2-h hyperinsulinemic - euglycemic clamp, both pre- and post -intervention. Twenty normal -weight individuals served as a control group and were examined at baseline only. Results: Individuals with overweight/obesity were characterized by a lower fasting serum ghrelin concentration than normal -weight individuals ( P = 0.006). Insulin decreased serum ghrelin concentration in both groups ( P < 0.001); however, this decrease was markedly lower in individuals with overweight/obesity than in normal -weight individuals (99.70 +/- 136.37 vs. 215.45 +/- 250.28 pg/mL; P = 0.026). Fasting serum ghrelin concentration increased after the intervention. After weight -reducing dietary intervention, the decrease in serum ghrelin concentration after the clamp was significantly greater than the pre -intervention value (99.70 +/- 136.37 vs. 221.82 +/- 228.75 pg/mL; P = 0.002). Conclusions: Weight -reducing dietary intervention restores the ability of hyperinsulinemia to suppress serum ghrelin concentration. It may suggest an enhanced feeling of satiety after moderate weight loss in individuals with overweight/obesity.

引用

页码：1631 / 1639

页数：9

共 37 条

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