The Role of Long Non-Coding RNF144A-AS1 in Cancer Progression

被引：2
作者：
Wu, Wei [1 ,2 ,3 ]
Li, Xiaolan [4 ,5 ]
Li, Xueqing [2 ,3 ]
Zhao, Jiale [1 ,2 ,3 ]
Gui, Yibei [1 ,2 ,6 ]
Luo, Yiyang [2 ,3 ]
Wang, Hailin [1 ,2 ,3 ]
Wang, Lijun [1 ,2 ,6 ]
Yuan, Chengfu [1 ,2 ,6 ]
机构：
[1] China Three Gorges Univ, Hubei Key Lab Tumor Microenvironm & Immunotherapy, Yichang 443002, Peoples R China
[2] China Three Gorges Univ, Third Grade Pharmacol Lab Tradit Chinese Med, State Adm Tradit Chinese Med, Yichang 443002, Peoples R China
[3] China Three Gorges Univ, Coll Med & Hlth Sci, Yichang 443002, Peoples R China
[4] China Three Gorges Univ, Peoples Hosp 2, Yichang 443002, Peoples R China
[5] Second Peoples Hosp Yichang, Yichang 443002, Peoples R China
[6] China Three Gorges Univ, Coll Basic Med Sci, Yichang 443002, Peoples R China
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2024年 / 82卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Long non-coding RNA; RNF144A-AS1; Cancer; Diagnosis; Prognostic; BLADDER-CANCER; CARCINOMA; SURVIVAL; HEAD; EXPRESSION; RESISTANCE; MELANOMA; AKT;
D O I：
10.1007/s12013-024-01411-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNAs transcribing more than 200 nucleotides without encoding proteins are termed long non-coding RNAs (LncRNAs). LncRNAs can be used as decoy molecules, signal molecules, scaffolds, and guide molecules. Long non-coding RNAs can interact with DNA, chromatin-modifying complexes, and transcriptional regulatory proteins, regulating gene expression in the cell nucleus. It is distributed in cytoplasm; they also participate in mRNA degradation and translational regulation via miRNAs, other transcription products, and proteins. They play a significant role in the development of various diseases, including tumors. Cancer seriously threatens human life and health. Regretfully, a great deal of newly diagnosed cancer patients found to have metastasized. RNF144A-AS1, also referred to as GRASLND, was initially recognized for its regulation of chondrogenic differentiation in MSCs. Focusing on RNF144A-AS1, this review summarizes and discusses the latest progress of RNF144A-AS1 in bladder cancer, glioblastoma, papillary renal cell carcinoma, gastric cancer, osteosarcoma, head and neck squamous cell carcinoma, and ovarian cancer. RNF144A-AS1 has good potential in tumor treatment and diagnosis. RNF144A-AS1 is abnormal expressed in cancer.RNF144A-AS1 is a tumor suppressor gene and an oncogene.RNF144A-AS1 is related to the prognosis of cancer patients.RNF144A-AS1 may be a new method for tumor detection and treatment.
引用
收藏
页码：2007 / 2017
页数：11
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