Do menthol and its derivatives present biological activity with antifungal potential?

被引：2

作者：

Teixeira, Anna Paula de Castro ^{[1
]}

Melo, Flaviana Maria de Sousa ^{[1
]}

Lima, Igara Oliveira ^{[2
]}

Pessoa, Hilzeth de Luna Freire ^{[1
]}

Sa, Rita ^{[1
]}

机构：

[1] Univ Fed Paraiba, Hlth Sci Ctr, Joao Pessoa, Brazil

[2] Univ Fed Campina Grande, Educ & Hlth Ctr, Cuite, Brazil

来源：

JOURNAL OF ESSENTIAL OIL RESEARCH | 2024年 / 36卷 / 04期

关键词：

Antifungal properties; biological activity; menthol derivatives; ESSENTIAL OILS; ANTIMICROBIAL ACTIVITY; MONOTERPENES; COMPONENTS;

D O I：

10.1080/10412905.2024.2376673

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Plants of the Mentha genus have been studied for their application as anti-inflammatory, analgesic and antimicrobial agents, with these effects being attributed to menthol, the majority compound. This review aims to compile research on the antifungal action of menthol and its derivatives. A search was conducted on the following databases: Web of Science, Medline/PubMed, Embase, The Cochrane Library, Scopus and Science Direct, using the descriptors 'menthol' and/or 'derivatives'. Twenty-six articles on in vitro studies were selected. Menthol showed activity mainly against Candida albicans, Candida krusei, Aspergillus flavus and Penicillium spp. with MICs 0.78-1000 mu g/mL and MFC 0.5-1000 mu g/mL. In combination with fluconazole, it presented a synergistic effect against Candida genus. However, there have been few studies on the mechanisms of action. Although the method and its derivatives are promising, further studies are needed to fully explore their effects.

引用

页码：291 / 320

页数：30

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