The role of RIPK1 in chronic obstructive pulmonary disease

被引：1

作者：

Tiwari, Aman ^{[1
]}

Gautam, Avtar Singh ^{[1
]}

Pandey, Shivam Kumar ^{[1
]}

Singh, Shreya ^{[1
]}

Singh, Rakesh Kumar ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res Raebareli NIPER Ra, Dept Pharmacol & Toxicol, Transit Campus,Bijnor Sisendi Rd, Lucknow 226002, Uttar Pradesh, India

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 07期

关键词：

RIPK1; lung in flammation; chronic obstructive pulmonary disease; necroptosis; lung remodelling; INDUCED NECROPTOSIS; CASPASE-8; ACTIVATION; CELL-DEATH; PATHOGENESIS;

D O I：

10.1016/j.drudis.2024.104020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Necroptosis has emerged as one of the crucial pathological processes involved in the regulation of cell death and inflammation in chronic obstructive pulmonary disease (COPD). Airway epithelial necroptosis is closely linked to COPD pathogenesis. Necroptotic lung cells can release damageassociated molecular patterns (DAMPs) that can initiate a robust inflammatory response. However, the underlying mechanism of necroptosis in COPD is still not clearly understood. Therefore, we aimed to explore the roles and mechanisms of receptor-interacting serine/threonine-protein kinase 1 (RIPK1)mediated necroptosis in the regulation of inflammatory responses in COPD to provide insights into RIPK1-inhibitor drug discovery efforts and their therapeutic benefits in COPD.

引用

页数：10

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