Serum vitamin D metabolite and acute-phase protein concentrations are frequently abnormal in a cohort of hospitalized dogs and cats

被引:0
作者
Rose, Hailey [1 ]
Jaffey, Jared A. [2 ]
Cammarano, Kellie [1 ]
Ringold, Randy [3 ]
Turner, Hailey D. [2 ]
McArdell, Kara [2 ]
Sender, David [2 ]
Loftus, John P. [1 ]
机构
[1] Cornell Univ, Coll Vet Med, Dept Clin Sci, Loftus Lab, Ithaca, NY 14850 USA
[2] Midwestern Univ, Coll Vet Med, Dept Specialty Med, Glendale, AZ 85308 USA
[3] Vet Diagnost Inst Lab LLC, Chatsworth, CA USA
来源
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION | 2024年 / 262卷 / 07期
关键词
vitamin D; acute-phase protein; calcitriol; canine; feline; ILLNESS STRATIFICATION SYSTEM; C-REACTIVE PROTEIN; THYMIDINE KINASE 1; CYTOKINE PRODUCTION; APPLE SCORE; SEPSIS; CALCITRIOL; EXPRESSION; SEVERITY;
D O I
10.2460/javma.23.12.0676
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
OBJECTIVE To determine whether serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH] 2 D) concentrations are associated with survival and negatively correlate with acute-phase protein (APP) concentrations in ill dogs and cats admitted to nursing care units. ANIMALS Client-owned dogs (n = 79) and cats (16) admitted to 2 academic veterinary hospital nursing care units. METHODS A prospective cohort study was conducted between August 12, 2019, and October 26, 2021. A diagnostic laboratory measured 25(OH)D, 1,25(OH) 2 D, and haptoglobin (HPT) in dogs and cats; C-reactive protein (CRP) in dogs; and serum amyloid A (SAA) in cats. Serum was collected within 12 hours of admission. Illness severity (acute patient physiologic and laboratory evaluation [APP LE fast ]) scores and survival data were recorded. RESULTS Serum 25(OH)D concentrations were in the deficient range for 22 of 79 dogs and 2 of 16 cats. There were no asso - ciations between serum analyte concentrations (25[OH]D, 1,25[OH] 2 D, and APP) or APPL E fast score and survival in dogs or cats. In dogs, HPT was negatively correlated with 25(OH)D ( P = .002; r = -0.34) and 1,25(OH) 2 D ( P = .012; r = -0.28), while CRP was positively correlated with HPT ( P = .001; r = 0.32) and APPL E fast score ( P = .014; r = 0.16). In cats, 1,25(OH) 2 D was negatively correlated with APPL E fast scores ( P = .055; r = -0.49) and SAA was positively cor - related with HPT ( P = .002; r = 0.73). CLINICAL RELEVANCE Serum 25(OH)D or 1,25(OH) 2 D was not associated with survival in our hospitalized patient population. Relationships between APP and serum vitamin D metabolites with APPL E fast scores in cats warrant further investigation as illness severity biomarkers.
引用
收藏
页码:928 / 939
页数:12
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