A comprehensive review on utilizing CRISPR/Cas system for microbiome modification

被引：6
作者：
Abavisani, Mohammad [1 ]
Faraji, Navid [1 ]
Faraji, Saba [1 ]
Ebadpour, Negar [2 ]
Kesharwani, Prashant [3 ]
Sahebkar, Amirhossein [4 ,5 ,6 ]
机构：
[1] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran
[2] Mashhad Univ Med Sci, Immunol Res Ctr, Mashhad, Iran
[3] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India
[4] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai, India
[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[6] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
来源：
BIOCHEMICAL ENGINEERING JOURNAL | 2024年 / 211卷
关键词：
CRISPR/Cas systems; Genetic engineering; Metagenomics; Microbiota; Health outcomes; RNA; PATHWAY; ENDONUCLEASE; COMMENSAL; IMMUNITY;
D O I：
10.1016/j.bej.2024.109443
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The recent advancements in biotechnology, particularly the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system inspired by bacterial defense mechanisms, have ushered in a new phase in gene editing. This system is now widely used for a range of purposes, including the diagnosis, treatment, and prevention of various diseases such as genetic conditions, cancer, infectious diseases, and issues related to antibiotic resistance. A particularly notable area of application is the alteration of the human gut microbiota, an essential and complex microbial ecosystem crucial for health. Imbalances in this system referred to as dysbiosis, are associated with several health issues, including heart disease, mental health disorders, and cancer. Therefore, the potential of manipulating microbiota for health benefits is significant. In accordance with this, recent research underscores the influence of modifying specific gut microbiota on the progression of diseases, notably in fields like oncology and inflammation. The current paper examines the impact of CRISPR technology in altering microbiota with the goal of exploiting its capabilities to improve human health. This exploration aims to move beyond theoretical research, applying CRISPR's sophisticated functions to complex and practical health scenarios with the ultimate objective of improving health outcomes.
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页数：12
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共 102 条
[11]  
Brophy JAN, 2014, NAT METHODS, V11, P508, DOI [10.1038/NMETH.2926, 10.1038/nmeth.2926]
[12]   Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells [J].
Campbell, Clarissa ;
McKenney, Peter T. ;
Konstantinovsky, Daniel ;
Isaeva, Olga I. ;
Schizas, Michail ;
Verter, Jacob ;
Mai, Cheryl ;
Jin, Wen-Bing ;
Guo, Chun-Jun ;
Violante, Sara ;
Ramos, Ruben J. ;
Cross, Justin R. ;
Kadaveru, Krishna ;
Hambor, John ;
Rudensky, Alexander Y. .
NATURE, 2020, 581 (7809) :475-+
[13]   RiboCas: A Universal CRISPR-Based Editing Tool for Clostridium [J].
Canadas, Ines C. ;
Groothuis, Daphne ;
Zygouropoulou, Maria ;
Rodrigues, Raquel ;
Minton, Nigel P. .
ACS SYNTHETIC BIOLOGY, 2019, 8 (06) :1379-1390
[14]   Panacea in progress: CRISPR and the future of its biological research introduction [J].
Carroll, Michael ;
Zhou, Xiaohui .
MICROBIOLOGICAL RESEARCH, 2017, 201 :63-74
[15]   Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota [J].
Chen, Danfeng ;
Jin, Duochen ;
Huang, Shumin ;
Wu, Jingyi ;
Xu, Mengque ;
Liu, Tianyu ;
Dong, Wenxiao ;
Liu, Xiang ;
Wang, Sinan ;
Zhong, Weilong ;
Liu, Yi ;
Jiang, Ruihuan ;
Piao, Meiyu ;
Wang, Bangmao ;
Cao, Hailong .
CANCER LETTERS, 2020, 469 :456-467
[16]   Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases [J].
Citorik, Robert J. ;
Mimee, Mark ;
Lu, Timothy K. .
NATURE BIOTECHNOLOGY, 2014, 32 (11) :1141-1145
[17]   Multiplex Genome Engineering Using CRISPR/Cas Systems [J].
Cong, Le ;
Ran, F. Ann ;
Cox, David ;
Lin, Shuailiang ;
Barretto, Robert ;
Habib, Naomi ;
Hsu, Patrick D. ;
Wu, Xuebing ;
Jiang, Wenyan ;
Marraffini, Luciano A. ;
Zhang, Feng .
SCIENCE, 2013, 339 (6121) :819-823
[18]   The gut microbiome in neurological disorders [J].
Cryan, John F. ;
O'Riordan, Kenneth J. ;
Sandhu, Kiran ;
Peterson, Veronica ;
Dinan, Timothy G. .
LANCET NEUROLOGY, 2020, 19 (02) :179-194
[19]   Novel genetic tools improve Penicillium expansum patulin synthase production in Aspergillus niger [J].
Dai, Ziyu .
FEBS JOURNAL, 2023, 290 (21) :5094-5097
[20]   Genus Streptomyces: Recent advances for biotechnological purposes [J].
de Lima Junior, Apolonio Alves ;
de Sousa, Ednan Cardoso ;
de Oliveira, Thales Henrique Barbosa ;
de Santana, Raphael Carlos Ferrer ;
da Silva, Silvia Katrine Rabelo ;
Coelho, Luana Cassandra Breitenbach Barroso .
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2023, 70 (04) :1504-1517
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