Stem Cell-Based Approaches in Parkinson's Disease Research

被引：3
作者：
Kim, Min Seong [1 ,2 ,9 ]
Yoon, Subeen [3 ]
Choi, Jiwoo [3 ]
Kim, Yong Jun [3 ,4 ,5 ,8 ]
Lee, Gabsang [1 ,2 ,6 ,7 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurol, 733 N Broadway, Baltimore, MD 21218 USA
[3] Kyung Hee Univ, Grad Sch, Dept Biomed Sci, 26 Kyungheedae-ro,Dongdaemun-gu, Seoul 02447, South Korea
[4] Kyung Hee Univ, Coll Med, Dept Pathol, Seoul, South Korea
[5] Kyung Hee Univ, Grad Sch, KHU KIST Dept Converging Sci & Technol, Seoul, South Korea
[6] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD USA
[7] Johns Hopkins Univ, Sch Med, Dept Neurol, 733 N Broadway, Baltimore, MD 21205 USA
[8] Kyung Hee Univ, Coll Med, Dept Pathol, 26 Kyungheedae, Seoul 02447, South Korea
[9] Sejong Univ, Dept Integrat Biosci & Biotechnol, Seoul, South Korea
来源：
INTERNATIONAL JOURNAL OF STEM CELLS | 2024年
基金：
新加坡国家研究基金会;
关键词：
Disease model; Parkinson disease; Stem cell therapy; Pathological mechanism; MIDBRAIN DOPAMINERGIC-NEURONS; PATHOLOGICAL ALPHA-SYNUCLEIN; MITOCHONDRIAL DYSFUNCTION; NEURAL STEM; FAMILIAL DYSAUTONOMIA; PROGENITOR CELLS; LYSOSOMAL DYSFUNCTION; BRAIN ORGANOIDS; IN-VIVO; LRRK2;
D O I：
10.15283/ijsc23169
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. While current treatments provide limited relief, they don't alter disease progression. Stem cell technology, involving patient-specific stem cell-derived neurons, offers a promising avenue for research and personalized regenerative therapies. This article reviews the potential of stem cell -based research in PD, summarizing ongoing efforts, their limitations, and introducing innovative research models. The integration of stem cell technology and advanced models promises to enhance our understanding and treatment strategies for PD.
引用
收藏
页码：21 / 36
页数：16
相关论文
共 168 条
  • [81] Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation
    Kurapati, Sravya
    Sadaoka, Tomohiko
    Rajbhandari, Labchan
    Jagdish, Balaji
    Shukla, Priya
    Ali, Mir A.
    Kim, Yong Jun
    Lee, Gabsang
    Cohen, Jeffrey I.
    Venkatesan, Arun
    [J]. JOURNAL OF VIROLOGY, 2017, 91 (17)
  • [82] Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling
    Kwak, Tae Hwan
    Kang, Ji Hyun
    Hali, Sai
    Kim, Jonghun
    Kim, Kee-Pyo
    Park, Chanhyeok
    Lee, Ju-Hyun
    Ryu, Ha Kyun
    Na, Ji Eun
    Jo, Junghyun
    Je, Hyunsoo Shawn
    Ng, Huck-Hui
    Kwon, Jeongwoo
    Kim, Nam-Hyung
    Hong, Kwon Ho
    Sun, Woong
    Chung, Chi Hye
    Rhyu, Im Joo
    Han, Dong Wook
    [J]. STEM CELLS, 2020, 38 (06) : 727 - 740
  • [83] Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential
    Kyttala, Aija
    Moraghebi, Roksana
    Valensisi, Cristina
    Kettunen, Johannes
    Andrus, Colin
    Pasumarthy, Kalyan Kumar
    Nakanishi, Mahito
    Nishimura, Ken
    Ohtaka, Manami
    Weltner, Jere
    Van Handel, Ben
    Parkkonen, Olavi
    Sinisalo, Juha
    Jalanko, Anu
    Hawkins, R. David
    Woods, Niels-Bjarne
    Otonkoski, Timo
    Trokovic, Ras
    [J]. STEM CELL REPORTS, 2016, 6 (02): : 200 - 212
  • [84] iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates
    Laperle, A. H.
    Sances, S.
    Yucer, N.
    Dardov, V. J.
    Garcia, V. J.
    Ho, R.
    Fulton, A. N.
    Jones, M. R.
    Roxas, K. M.
    Avalos, P.
    West, D.
    Banuelos, M. G.
    Shu, Z.
    Murali, R.
    Maidment, N. T.
    Van Eyk, J. E.
    Tagliati, M.
    Svendsen, C. N.
    [J]. NATURE MEDICINE, 2020, 26 (02) : 289 - +
  • [85] Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
    Lee, Gabsang
    Ramirez, Christina N.
    Kim, Hyesoo
    Zeltner, Nadja
    Liu, Becky
    Radu, Constantin
    Bhinder, Bhavneet
    Kim, Yong Jun
    Choi, In Young
    Mukherjee-Clavin, Bipasha
    Djaballah, Hakim
    Studer, Lorenz
    [J]. NATURE BIOTECHNOLOGY, 2012, 30 (12) : 1244 - +
  • [86] Modelling familial dysautonomia in human induced pluripotent stem cells
    Lee, Gabsang
    Studer, Lorenz
    [J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2011, 366 (1575) : 2286 - 2296
  • [87] Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Lee, Gabsang
    Papapetrou, Eirini P.
    Kim, Hyesoo
    Chambers, Stuart M.
    Tomishima, Mark J.
    Fasano, Christopher A.
    Ganat, Yosif M.
    Menon, Jayanthi
    Shimizu, Fumiko
    Viale, Agnes
    Tabar, Viviane
    Sadelain, Michel
    Studer, Lorenz
    [J]. NATURE, 2009, 461 (7262) : 402 - U100
  • [88] Mechanisms of Parkinson's disease linked to pathological α-synuclein:: New targets for drug discovery
    Lee, Virginia M. -Y.
    Trojanowski, John Q.
    [J]. NEURON, 2006, 52 (01) : 33 - 38
  • [89] Levodopa therapy for Parkinson disease A look backward and forward
    LeWitt, Peter A.
    Fahn, Stanley
    [J]. NEUROLOGY, 2016, 86 (14) : S3 - S12
  • [90] Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    Li, Jia-Yi
    Englund, Elisabet
    Holton, Janice L.
    Soulet, Denis
    Hagell, Peter
    Lees, Andrew J.
    Lashley, Tammaryn
    Quinn, Niall P.
    Rehncrona, Stig
    Bjorklund, Anders
    Widner, Hakan
    Revesz, Tamas
    Lindvall, Olle
    Brundin, Patrik
    [J]. NATURE MEDICINE, 2008, 14 (05) : 501 - 503
45678910111213