Omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases

被引：7

作者：

Tutor, Austin ^{[1
]}

O'Keefe, Evan L. ^{[2
,3
]}

Lavie, Carl J. ^{[1
]}

Elagizi, Andrew ^{[4
]}

Milani, Richard ^{[5
]}

O'Keefe, James ^{[2
,3
]}

机构：

[1] Univ Queensland, John Ochsner Heart & Vasc Inst, Ochsner Clin Sch, Dept Cardiovasc Dis,Sch Med, New Orleans, LA USA

[2] St Lukes Mid Amer Heart Inst, Kansas City, MO USA

[3] Univ Missouri Kansas City, Kansas City, MO USA

[4] Southlake Reg Hlth Ctr, Dept Cardiovasc Dis, 596 Davis Dr, Newmarket, ON L3Y 2P9, Canada

[5] Pier One, Sutter Hlth, Ctr Clin Innovat, Bay 1A, San Francisco, CA 94111 USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2024年 / 84卷

关键词：

Omega-3 polyunsaturated fatty acids; Fish oil; Cardiovascular disease; Myocardial infarction; POLYUNSATURATED FATTY-ACIDS; FISH CONSUMPTION; EICOSAPENTAENOIC ACID; HEART-FAILURE; HYPERCHOLESTEROLEMIC PATIENTS; RISK; SUPPLEMENTATION; MORTALITY; EVENTS; STROKE;

D O I：

10.1016/j.pcad.2024.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Even with substantial progress in primary and secondary prevention, cardiovascular disease (CVD) persists as a major cause of mortality and morbidity globally. Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) have gained considerable attention for their ability to improve CV health and prognosis. Metanalyses of randomized controlled trials have demonstrated Omega-3 PUFAs' positive impact on CVD outcomes for both primary and secondary prevention endpoints. Marine Omega-3 PUFAs also improve CVD risk factors including blood pressure, lipids, and inflammation; however, many physicians do not recommend Omega-3 PUFAs, largely due to inconsistent results in randomized trials. In this comprehensive review article, we evaluate both historic and current data concerning primary and secondary prevention of CVD with use of Omega-3 PUFAs, delve into the potential causes for the varied results, and examine the most current recommendations on the usage of Omega-3 PUFAs.

引用

页码：19 / 26

页数：8