Hormone Receptor Expression and Activity for Different Tumour Locations in Patients with Advanced and Recurrent Endometrial Carcinoma

被引：1

作者：

Luijten, Maartje M. W. ^{[1
,2
]}

van Weelden, Willem Jan ^{[1
,3
]}

Lalisang, Roy I. ^{[4
]}

Bulten, Johan ^{[5
]}

Lindemann, Kristina ^{[6
,7
]}

van Beekhuizen, Heleen J. ^{[8
]}

Trum, Hans ^{[9
]}

Boll, Dorry ^{[10
]}

Werner, Henrica M. J. ^{[11
]}

van Lonkhuijzen, Luc R. C. W. ^{[12
]}

Yigit, Refika ^{[13
]}

Krakstad, Camilla ^{[14
]}

Witteveen, Petronella O. ^{[15
]}

Galaal, Khadra ^{[16
]}

van Ginkel, Alexandra A. ^{[2
]}

Bignotti, Eliana ^{[17
]}

Weinberger, Vit ^{[18
,19
]}

Sweegers, Sanne ^{[1
]}

Eriksson, Ane Gerda Z. ^{[6
,7
]}

Keizer, Diederick M. ^{[20
]}

van de Stolpe, Anja ^{[21
]}

Romano, Andrea ^{[4
,11
]}

Pijnenborg, Johanna M. A. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynaecol, NL-6525 GA Nijmegen, Netherlands

[2] Rijnstate Hosp, Dept Gynaecol, NL-6815 AD Arnhem, Netherlands

[3] Canisius Wilhelmina Hosp, Dept Obstet & Gynaecol, NL-6532 SZ Nijmegen, Netherlands

[4] Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, NL-6229 ER Maastricht, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6525 GA Nijmegen, Netherlands

[6] Oslo Univ Hosp, Div Med, Dept Gynecol Oncol, N-0424 Oslo, Norway

[7] Univ Oslo, Inst Clin Med, Fac Med, N-0450 Oslo, Norway

[8] Erasmus MC, Erasmus MC Canc Inst, Dept Gynecol Oncol, NL-3015 GD Rotterdam, Netherlands

[9] Netherlands Canc Inst, Ctr Gynecol Oncol Amsterdam, NL-1066 CX Amsterdam, Netherlands

[10] Catharina Hosp, Dept Gynaecol, NL-5623 EJ Eindhoven, Netherlands

[11] Maastricht Univ, Med Ctr, Dept Obstet & Gynecol, NL-6229 HX Maastricht, Netherlands

[12] Univ Amsterdam, Med Ctr, Dept Gynaecol & Obstet, NL-1105 AZ Amsterdam, Netherlands

[13] Univ Med Ctr Groningen, Dept Obstet & Gynecol, NL-9713 GZ Groningen, Netherlands

[14] Haukeland Hosp, Dept Gynecol & Obstet, N-5009 Bergen, Norway

[15] Univ Med Ctr Utrecht, Dept Med Oncol, NL-3584 CX Utrecht, Netherlands

[16] Sultan Qaboos Comprehens Canc Ctr, POB 566, Muscat 123, Oman

[17] ASST Spedali Civili Brescia, A Nocivelli Inst Mol Med, Div Obstet & Gynecol, I-25123 Brescia, Italy

[18] Masaryk Univ, Fac Med, Dept Obstet & Gynecol, Brno 62500, Czech Republic

[19] Univ Hosp Brno, Dept Obstet & Gynecol, Brno 62500, Czech Republic

[20] InnoSIGN, NL-5656 AE Eindhoven, Netherlands

[21] DCDC Tx BV, NL-5263 EM Vught, Netherlands

来源：

CANCERS | 2024年 / 16卷 / 11期

关键词：

endometrial cancer; hormone receptor; tumour location; PROGESTERONE-RECEPTOR; CANCER; RADIOTHERAPY; CARBOPLATIN; PACLITAXEL; THERAPY; IRRADIATION; PROGRESSION; METASTASIS; ESTROGEN;

D O I：

10.3390/cancers16112084

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Response to hormonal therapy in advanced and recurrent endometrial cancer (EC) can be predicted by oestrogen and progesterone receptor immunohistochemical (ER/PR-IHC) expression, with response rates of 60% in PR-IHC > 50% cases. ER/PR-IHC can vary by tumour location and is frequently lost with tumour progression. Therefore, we explored the relationship between ER/PR-IHC expression and tumour location in EC. Methods: Pre-treatment tumour biopsies from 6 different sites of 80 cases treated with hormonal therapy were analysed for ER/PR-IHC expression and classified into categories 0-10%, 10-50%, and >50%. The ER pathway activity score (ERPAS) was determined based on mRNA levels of ER-related target genes, reflecting the actual activity of the ER receptor. Results: There was a trend towards lower PR-IHC (33% had PR > 50%) and ERPAS (27% had ERPAS > 15) in lymphogenic metastases compared to other locations (p = 0.074). Hematogenous and intra-abdominal metastases appeared to have high ER/PR-IHC and ERPAS (85% and 89% ER-IHC > 50%; 64% and 78% PR-IHC > 50%; 60% and 71% ERPAS > 15, not significant). Tumour grade and previous radiotherapy did not affect ER/PR-IHC or ERPAS. Conclusions: A trend towards lower PR-IHC and ERPAS was observed in lymphogenic sites. Verification in larger cohorts is needed to confirm these findings, which may have implications for the use of hormonal therapy in the future.

引用

页数：19

共 50 条

[41] Advanced and recurrent endometrial cancer: State of the art and future perspectives [J].

Tronconi, Francesca ;

Nero, Camilla ;

Giudice, Elena ;

Salutari, Vanda ;

Musacchio, Lucia ;

Ricci, Caterina ;

Carbone, Maria Vittoria ;

Ghizzoni, Viola ;

Perri, Maria Teresa ;

Camarda, Floriana ;

Gentile, Marica ;

Berardi, Rossana ;

Scambia, Giovanni ;

Lorusso, Domenica .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2022, 180

[42] Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial [J].

Trovik, Jone ;

Wik, Elisabeth ;

Werner, Henrica M. J. ;

Krakstad, Camilla ;

Helland, Harald ;

Vandenput, Ingrid ;

Njolstad, Tormund S. ;

Stefansson, Ingunn M. ;

Marcickiewicz, Janusz ;

Tingulstad, Solveig ;

Staff, Anne C. ;

Amant, Frederic ;

Akslen, Lars A. ;

Salvesen, Helga B. .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (16) :3431-3441

[43] Progesterone Inhibits Epithelial-to-Mesenchymal Transition in Endometrial Cancer [J].

van der Horst, Paul H. ;

Wang, Yongyi ;

Vandenput, Ingrid ;

Kuhne, Liesbeth C. ;

Ewing, Patricia C. ;

van IJcken, Wilfred F. J. ;

van der Zee, Marten ;

Amant, Frederic ;

Burger, Curt W. ;

Blok, Leen J. .

PLOS ONE, 2012, 7 (01)

[44] Added Value of Estrogen Receptor, Progesterone Receptor, and L1 Cell Adhesion Molecule Expression to Histology-Based Endometrial Carcinoma Recurrence Prediction Models: An ENITEC Collaboration Study [J].

van der Putten, Louis J. M. ;

Visser, Nicole C. M. ;

van de Vijver, Koen ;

Santacana, Maria ;

Bronsert, Peter ;

Bulten, Johan ;

Hirschfeld, Marc ;

Colas, Eva ;

Gil-Moreno, Antonio ;

Garcia, Angel ;

Mancebo, Gemma ;

Alameda, Fransesc ;

Trovik, Jone ;

Kopperud, Reidun K. ;

Huvila, Jutta ;

Schrauwen, Stefanie ;

Koskas, Martin ;

Walker, Francine ;

Weinberger, Vit ;

Minar, Lubos ;

Jandakova, Eva ;

Snijders, Marc P. L. M. ;

van den Berg-van Erp, Saskia ;

Matias-Guiu, Xavier ;

Salvesen, Helga B. ;

Werner, Henrica M. J. ;

Amant, Frederic ;

Massuger, Leon F. A. G. ;

Pijnenborg, Johanna M. A. .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2018, 28 (03) :514-523

[45] L1CAM expression in endometrial carcinomas: an ENITEC collaboration study [J].

van der Putten, Louis J. M. ;

Visser, Nicole C. M. ;

van de Vijver, Koen ;

Santacana, Maria ;

Bronsert, Peter ;

Bulten, Johan ;

Hirschfeld, Marc ;

Colas, Eva ;

Gil-Moreno, Antonio ;

Garcia, Angel ;

Mancebo, Gemma ;

Alameda, Fransesc ;

Trovik, Jone ;

Kopperud, Reidun K. ;

Huvila, Jutta ;

Schrauwen, Stefanie ;

Koskas, Martin ;

Walker, Francine ;

Weinberger, Vit ;

Minar, Lubos ;

Jandakova, Eva ;

Snijders, Marc P. L. M. ;

van den Berg-van Erp, Saskia ;

Matias-Guiu, Xavier ;

Salvesen, Helga B. ;

Amant, Frederic ;

Massuger, Leon F. A. G. ;

Pijnenborg, Johanna M. A. .

BRITISH JOURNAL OF CANCER, 2016, 115 (06) :716-724

[46] Impact of hormonal biomarkers on response to hormonal therapy in advanced and recurrent endometrial cancer [J].

van Weelden, Willem Jan ;

Lalisang, Roy I. ;

Bulten, Johan ;

Lindemann, Kristina ;

van Beekhuizen, Heleen J. ;

Trum, Hans ;

Boll, Dorry ;

Werner, Henrica M. J. ;

van Lonkhuijzen, Luc R. C. W. ;

Yigit, Refika ;

Forsse, David ;

Witteveen, Petronella O. ;

Galaal, Khadra ;

van Ginkel, Alexandra ;

Bignotti, Eliana ;

Weinberger, Vit ;

Sweegers, Sanne ;

Kroep, Judith R. ;

Cabrera, Silvia ;

Snijders, Marc P. L. M. ;

Inda, Marcia A. ;

Eriksson, Ane Gerda Z. ;

Krakstad, Camilla ;

Romano, Andrea ;

van de Stolpe, Anja ;

Pijnenborg, Johanna M. A. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2021, 225 (04)

[47] Oestrogen receptor pathway activity is associated with outcome in endometrial cancer [J].

van Weelden, Willem Jan ;

van der Putten, Louis J. M. ;

Inda, Marcia A. ;

van Brussel, Anne ;

Snijders, Marc P. L. M. ;

Schriever, Lisanne M. M. ;

Bulten, Johan ;

Massuger, Leon F. A. G. ;

van de Stolpe, Anja ;

Pijnenborg, Johanna M. A. .

BRITISH JOURNAL OF CANCER, 2020, 123 (05) :785-792

[48] Anti-estrogen Treatment in Endometrial Cancer: A Systematic Review [J].

van Weelden, Willem Jan ;

Massuger, Leon F. A. G. ;

Pijnenborg, Johanna M. A. ;

Romano, Andrea .

FRONTIERS IN ONCOLOGY, 2019, 9

[49] Selection of Personalized Patient Therapy through the Use of Knowledge-Based Computational Models That Identify Tumor-Driving Signal Transduction Pathways [J].

Verhaegh, Wim ;

van Ooijen, Henk ;

Inda, Marcia A. ;

Hatzis, Pantelis ;

Versteeg, Rogier ;

Smid, Marcel ;

Martens, John ;

Foekens, John ;

van de Wiel, Paul ;

Clevers, Hans ;

van de Stolpe, Anja .

CANCER RESEARCH, 2014, 74 (11) :2936-2945

[50] Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: improving patient selection for adjuvant therapy [J].

Wortman, B. G. ;

Creutzberg, C. L. ;

Putter, H. ;

Jurgenliemk-Schulz, I. M. ;

Jobsen, J. J. ;

Lutgens, L. C. H. W. ;

van der Steen-Banasik, E. M. ;

Mens, J. W. M. ;

Slot, A. ;

Kroese, M. C. Stenfert ;

van Triest, B. ;

Nijman, H. W. ;

Stelloo, E. ;

Bosse, T. ;

de Boer, S. M. ;

van Putten, W. L. J. ;

Smit, V. T. H. B. M. ;

Nout, R. A. .

BRITISH JOURNAL OF CANCER, 2018, 119 (09) :1067-1074

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