Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

被引：14

作者：

Morales-Duran, Nami ^{[1
,2
]}

Leon-Buitimea, Angel ^{[1
,2
]}

Morones-Ramirez, Jose R. ^{[1
,2
]}

机构：

[1] Univ Autonoma Nuevo Leon UANL, Fac Ciencias Quim, San Nicolas De Los Garza 66455, Mexico

[2] Univ Autonoma Nuevo Leon, Fac Ciencias Quim, Ctr Invest Biotecnol & Nanotecnol, Parque Invest Innovac Tecnol, Apodaca 66628, Mexico

来源：

HELIYON | 2024年 / 10卷 / 06期

关键词：

Combination therapy; Monotherapies; Antimicrobial resistance; Multi-resistant bacteria; ANTIBIOTIC-RESISTANCE; MYCOBACTERIUM-TUBERCULOSIS; DRUG-RESISTANCE; FITNESS COSTS; IN-VITRO; BIOINFORMATICS; NANOPARTICLES; INFECTIONS; EMERGENCE; SYNERGY;

D O I：

10.1016/j.heliyon.2024.e27984

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are the main drivers in developing drug -resistant bacteria. The emergence of the rapid global spread of multi -resistant bacteria requires urgent multisectoral action to generate novel treatment alternatives. Combination therapy offers the potential to exploit synergistic effects for enhanced antibacterial efficacy of drugs. Understanding the complex dynamics and kinetics of drug interactions in combination therapy is crucial. Therefore, this review outlines the current advances in antibiotic resistance 's evolutionary and genetic dynamics in combination therapies -exposed bacteria. Moreover, we also discussed four pivotal future research areas to comprehend better the development of antibiotic resistance in bacteria treated with combination strategies.

引用

页数：10

共 105 条

[1] Re-sensitizing Ampicillin and Kanamycin-ResistantE. coliandS. aureusUsing Synergistic Metal Micronutrients-Antibiotic Combinations [J].

Alberto Garza-Cervantes, Javier ;

Meza-Bustillos, Jesus F. ;

Resendiz-Hernandez, Haziel ;

Suarez-Cantu, Ivan A. ;

Antonio Ortega-Rivera, Oscar ;

Salinas, Eva ;

Enrique Escarcega-Gonzalez, Carlos ;

Ruben Morones-Ramirez, Jose .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8 (08)

[2]

Allahverdiyev AM, 2011, EXPERT REV ANTI-INFE, V9, P1035, DOI [10.1586/ERI.11.121, 10.1586/eri.11.121]

[3] Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting [J].

Angst, Daniel C. ;

Tepekule, Burcu ;

Sun, Lei ;

Bogos, Balazs ;

Bonhoeffer, Sebastian .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (13)

[4] Antimicrobial stewardship programmes in health-care facilities in low- and middle-income countries: a WHO practical toolkit [J].

不详 .

JAC-ANTIMICROBIAL RESISTANCE, 2019, 1 (03)

[5]

[Anonymous], 2021, WHO announces updated definitions of extensively drug-resistant tuberculosis

[6] Fifty important research questions in microbial ecology [J].

Antwis, Rachael E. ;

Griffiths, Sarah M. ;

Harrison, Xavier A. ;

Aranega-Bou, Paz ;

Arce, Andres ;

Bettridge, Aimee S. ;

Brailsford, Francesca L. ;

de Menezes, Alexandre ;

Devaynes, Andrew ;

Forbes, Kristian M. ;

Fry, Ellen L. ;

Goodhead, Ian ;

Haskell, Erin ;

Heys, Chloe ;

James, Chloe ;

Johnston, Sarah R. ;

Lewis, Gillian R. ;

Lewis, Zenobia ;

Macey, Michael C. ;

McCarthy, Alan ;

McDonald, James E. ;

Mejia-Florez, Nasmille L. ;

O'Brien, David ;

Orland, Chloe ;

Pautasso, Marco ;

Reid, William D. K. ;

Robinson, Heather A. ;

Wilson, Kenneth ;

Sutherland, William J. .

FEMS MICROBIOLOGY ECOLOGY, 2017, 93 (05)

[7] Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens [J].

Baker, Stephen ;

Thomson, Nicholas ;

Weill, Francois-Xavier ;

Holt, Kathryn E. .

SCIENCE, 2018, 360 (6390) :733-738

[8] Bringing Community Ecology to Bear on the Issue of Antimicrobial Resistance [J].

Banerji, Aabir ;

Jahne, Michael ;

Herrmann, Michael ;

Brinkman, Nichole ;

Keely, Scott .

FRONTIERS IN MICROBIOLOGY, 2019, 10

[9] Nano-Strategies to Fight Multidrug Resistant Bacteria-"A Battle of the Titans" [J].

Baptista, Pedro V. ;

McCusker, Matthew P. ;

Carvalho, Andreia ;

Ferreira, Daniela A. ;

Mohan, Niamh M. ;

Martins, Marta ;

Fernandes, Alexandra R. .

FRONTIERS IN MICROBIOLOGY, 2018, 9

[10] In vitro synergy testing of novel antimicrobial combination therapies against Neisseria gonorrhoeae [J].

Barbee, Lindley A. ;

Soge, Olusegun O. ;

Holmes, King K. ;

Golden, Matthew R. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (06) :1572-1578

← 1 2 3 4 5 6 7 8 9 10 →