Epithelial-neuronal-immune cell interactions: Implications for immunity, inflammation, and tissue homeostasis at mucosal sites

被引：7
作者：
Emanuel, Elizabeth [1 ,2 ]
Arifuzzaman, Mohammad [1 ]
Artis, David [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Cornell Univ, Jill Roberts Inst Res Inflammatory Bowel Dis, Joan & Sanford I Weill Dept Med, Dept Microbiol & Immunol,Weill Cornell Med, New York, NY USA
[2] Weill Cornell Med, Immunol & Microbial Pathogenesis Program, New York, NY USA
[3] Cornell Univ, Friedman Ctr Nutr & Inflammat, Joan & Sanford I Weill Dept Med, Dept Microbiol & Immunol,Weill Cornell Med, New York, NY USA
[4] Allen Discovery Ctr Neuroimmune Interact, New York, NY USA
[5] Weill Cornell Med, Dept Microbiol & Immunol, New York, NY USA
[6] Cornell Univ, Jill Roberts Inst Res Inflammatory Bowel Dis, Dept Med, Dept Microbiol & Immunol,Weill Cornell Med, 413 East 69th St, New York, NY 10021 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2024年 / 153卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Epithelium; airway inflammation; intestinal inflamma- tion; neuroimmunity; immune regulation; asthma; allergy; mucosal immunity; INNATE LYMPHOID-CELLS; PROMOTES FOOD ANAPHYLAXIS; BARRIER FUNCTION; TYPE-2; IMMUNITY; RETINOIC ACID; GOBLET CELLS; TUFT CELLS; CHEMOSENSORY CELLS; IL-33; PROMOTES; COLON-CANCER;
D O I：
10.1016/j.jaci.2024.02.004
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The epithelial lining of the respiratory tract and intestine provides a critical physical barrier to protect host tissues against environmental insults, including dietary antigens, allergens, chemicals, and microorganisms. In addition, specialized epithelial cells communicate directly with hematopoietic and neuronal cells. These epithelial-immune and epithelial-neuronal interactions control host immune responses and have important implications for inflammatory conditions associated with defects in the epithelial barrier, including asthma, allergy, and inflammatory bowel diseases. In this review, we discuss emerging research that identifies the mechanisms and impact of epithelial-immune and epithelial-neuronal cross talk in regulating immunity, inflammation, and tissue homeostasis at mucosal barrier surfaces. Understanding the regulation and impact of these pathways could provide new therapeutic targets for inflammatory diseases at mucosal sites. (J Allergy Clin Immunol 2024;153:1169-80.)
引用
收藏
页码：1169 / 1180
页数：12
相关论文
共 177 条
[71]   Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity [J].
Jarret, Abigail ;
Jackson, Ruaidhri ;
Duizer, Coco ;
Healy, Marc E. ;
Zhao, Jun ;
Rone, Joseph M. ;
Bielecki, Piotr ;
Sefik, Esen ;
Roulis, Manolis ;
Rice, Tyler ;
Sivanathan, Kisha N. ;
Zhou, Ting ;
Solis, Angel G. ;
Honcharova-Biletska, Hanna ;
Velez, Karelia ;
Hartner, Saskia ;
Low, Jun Siong ;
Qu, Rihao ;
de Zoete, Marcel R. ;
Palm, Noah W. ;
Ring, Aaron M. ;
Weber, Achim ;
Moor, Andreas E. ;
Kluger, Yuval ;
Nowarski, Roni ;
Flavell, Richard A. .
CELL, 2020, 180 (01) :50-+
[72]   Comparison of two human organoid models of lung and intestinal inflammation reveals Toll-like receptor signalling activation and monocyte recruitment [J].
Jose, Shyam Sushama ;
De Zuani, Marco ;
Tidu, Federico ;
Kohoutkova, Marcela Hortova ;
Pazzagli, Lucia ;
Forte, Giancarlo ;
Spaccapelo, Roberta ;
Zelante, Teresa ;
Fric, Jan .
CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2020, 9 (05)
[73]   Neuro-immune crosstalk and allergic inflammation [J].
Kabata, Hiroki ;
Artis, David .
JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (04) :1475-1482
[74]   Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction [J].
Kaelberer, Melanie Maya ;
Rupprecht, Laura E. ;
Liu, Winston W. ;
Weng, Peter ;
Bohorquez, Diego V. .
ANNUAL REVIEW OF NEUROSCIENCE, VOL 43, 2020, 43 :337-353
[75]   A gut-brain neural circuit for nutrient sensory transduction [J].
Kaelberer, Melanie Maya ;
Buchanan, Kelly L. ;
Klein, Marguerita E. ;
Barth, Bradley B. ;
Montoya, Marcia M. ;
Shen, Xiling ;
Bohorquez, Diego V. .
SCIENCE, 2018, 361 (6408) :1219-+
[76]   TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells [J].
Kaske, Silke ;
Krasteva, Gabriele ;
Koenig, Peter ;
Kummer, Wolfgang ;
Hofmann, Thomas ;
Gudermann, Thomas ;
Chubanov, Vladimir .
BMC NEUROSCIENCE, 2007, 8 (1)
[77]   Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity [J].
Katheder, Nadja S. ;
Browder, Kristen C. ;
Chang, Diana ;
De Maziere, Ann ;
Kujala, Pekka ;
van Dijk, Suzanne ;
Klumperman, Judith ;
Lu, Tzu-Chiao ;
Li, Hongjie ;
Lai, Zijuan ;
Sangaraju, Dewakar ;
Jasper, Heinrich .
ELIFE, 2023, 12
[78]   A nerve-goblet cell association promotes allergic conjunctivitis through rapid [J].
Kimura, Meiko ;
Ando, Tomoaki ;
Kume, Yasuharu ;
Fukase, Saaya ;
Matsuzawa, Moe ;
Kashiwagi, Kosuke ;
Izawa, Kumi ;
Kaitani, Ayako ;
Nakano, Nobuhiro ;
Maeda, Keiko ;
Ogawa, Hideoki ;
Okumura, Ko ;
Nakao, Shintaro ;
Murakami, Akira ;
Ebihara, Nobuyuki ;
Kitaura, Jiro .
JCI INSIGHT, 2023, 8 (21)
[79]   Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model [J].
Kirchberger, Stefanie ;
Royston, Daniel J. ;
Boulard, Olivier ;
Thornton, Emily ;
Franchini, Fanny ;
Szabady, Rose L. ;
Harrison, Oliver ;
Powrie, Fiona .
JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (05) :917-931
[80]   Airway Innervation and Plasticity in Asthma [J].
Kistemaker, L. E. M. ;
Prakash, Y. S. .
PHYSIOLOGY, 2019, 34 (04) :283-298
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