Epithelial-neuronal-immune cell interactions: Implications for immunity, inflammation, and tissue homeostasis at mucosal sites

被引：7

作者：

Emanuel, Elizabeth ^{[1
,2
]}

Arifuzzaman, Mohammad ^{[1
]}

Artis, David ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Cornell Univ, Jill Roberts Inst Res Inflammatory Bowel Dis, Joan & Sanford I Weill Dept Med, Dept Microbiol & Immunol,Weill Cornell Med, New York, NY USA

[2] Weill Cornell Med, Immunol & Microbial Pathogenesis Program, New York, NY USA

[3] Cornell Univ, Friedman Ctr Nutr & Inflammat, Joan & Sanford I Weill Dept Med, Dept Microbiol & Immunol,Weill Cornell Med, New York, NY USA

[4] Allen Discovery Ctr Neuroimmune Interact, New York, NY USA

[5] Weill Cornell Med, Dept Microbiol & Immunol, New York, NY USA

[6] Cornell Univ, Jill Roberts Inst Res Inflammatory Bowel Dis, Dept Med, Dept Microbiol & Immunol,Weill Cornell Med, 413 East 69th St, New York, NY 10021 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2024年 / 153卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Epithelium; airway inflammation; intestinal inflamma- tion; neuroimmunity; immune regulation; asthma; allergy; mucosal immunity; INNATE LYMPHOID-CELLS; PROMOTES FOOD ANAPHYLAXIS; BARRIER FUNCTION; TYPE-2; IMMUNITY; RETINOIC ACID; GOBLET CELLS; TUFT CELLS; CHEMOSENSORY CELLS; IL-33; PROMOTES; COLON-CANCER;

D O I：

10.1016/j.jaci.2024.02.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The epithelial lining of the respiratory tract and intestine provides a critical physical barrier to protect host tissues against environmental insults, including dietary antigens, allergens, chemicals, and microorganisms. In addition, specialized epithelial cells communicate directly with hematopoietic and neuronal cells. These epithelial-immune and epithelial-neuronal interactions control host immune responses and have important implications for inflammatory conditions associated with defects in the epithelial barrier, including asthma, allergy, and inflammatory bowel diseases. In this review, we discuss emerging research that identifies the mechanisms and impact of epithelial-immune and epithelial-neuronal cross talk in regulating immunity, inflammation, and tissue homeostasis at mucosal barrier surfaces. Understanding the regulation and impact of these pathways could provide new therapeutic targets for inflammatory diseases at mucosal sites. (J Allergy Clin Immunol 2024;153:1169-80.)

引用

页码：1169 / 1180

页数：12

共 177 条

[121] Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut [J].