Blood proteomics of COVID-19 infection: An update

被引：3

作者：

Alexovic, Michal ^{[1
]}

Bondarchuk, Tetiana ^{[2
]}

Ulicna, Csilla ^{[1
,3
]}

Sabo, Jan

机构：

[1] Univ PJ Safarik Kosice, Fac Med, Dept Med & Clin Biophys, SK-04011 Kosice, Slovakia

[2] NAS Ukraine, Inst Mol Biol & Genet, UA-03143 Kyiv, Ukraine

[3] Presov Univ, Univ Lib, Presov 08001, Slovakia

来源：

CLINICA CHIMICA ACTA | 2024年 / 562卷

关键词：

Blood proteomics; Biomarker; COVID-19; Mass spectrometry; Sample preparation; SARS-CoV-2; Virus infection; SAMPLE PREPARATION; PROTEIN; ELECTROPHORESIS;

D O I：

10.1016/j.cca.2024.119881

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Despite significant progress in understanding SARS-CoV-2 and its impact, a deeper comprehension of the molecular changes in the host following infection is still lacking. Proteomic analysis of COVID-19 infected patients can provide valuable data about the events and mechanisms related to the initial, progression, and terminal stages of the disease. Such information can lead to better prevention, treatment, and convalescence strategies. In this review, we discuss blood proteomic studies based on mass spectrometry in COVID-19 patients. The analysis focuses on various blood components including plasma, platelets, serum, red blood cells, and peripheral blood mononuclear cells. Scientific papers published since 2022 are covered, with approaches categorised based on whether they use in-gel, in-solution, or on-beads/on-filter digestion modes. Additionally, candidate protein biomarkers related to COVID-19 are surveyed and discussed.

引用

页数：17

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