Sex and gender differences in cognitive resilience to aging and Alzheimer's disease

被引：62

作者：

Arenaza-Urquijo, Eider M. ^{[1
,2
]}

Boyle, Rory ^{[3
]}

Casaletto, Kaitlin ^{[4
]}

Anstey, Kaarin J. ^{[5
,6
,7
]}

Vila-Castelar, Clara ^{[3
]}

Colverson, Aaron ^{[8
]}

Palpatzis, Eleni ^{[1
,2
]}

Eissman, Jaclyn M. ^{[9
,10
]}

Ng, Ted Kheng Siang ^{[11
,12
]}

Raghavan, Sheelakumari ^{[13
]}

Akinci, Muge ^{[1
,2
]}

Vonk, Jet M. J. ^{[4
]}

Machado, Luiza S. ^{[14
]}

Zanwar, Preeti P. ^{[15
,16
]}

Shrestha, Hom L. ^{[17
]}

Wagner, Maude ^{[18
]}

Tamburin, Stefano ^{[19
]}

Sohrabi, Hamid R. ^{[20
,21
]}

Loi, Samantha ^{[22
,23
]}

Bartres-Faz, David ^{[24
,25
,26
,27
]}

Dubal, Dena B. ^{[28
,29
,30
]}

Prashanthi, Vemuri ^{[13
]}

Okonkwo, Ozioma ^{[31
,32
]}

Hohman, Timothy J. ^{[9
,10
]}

Ewers, Michael ^{[33
,34
]}

Buckley, Rachel F. ^{[3
]}

机构：

[1] Barcelona Inst Global Hlth ISGlobal, Environm & Hlth Life Course Programme, Climate Air Pollut Nat & Urban Hlth Programme, Barcelona Biomed Res Pk PRBB,C Dr Aiguader 88, Barcelona 08003, Spain

[2] Univ Pompeu Fabra, Barcelona, Spain

[3] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA USA

[4] Univ Calif San Francisco, Dept Neurol, Mem & Aging Ctr, San Francisco, CA USA

[5] Univ New South Wales, Ageing Futures Inst, Sydney, NSW, Australia

[6] Neurosci Res Australia, Sydney, NSW, Australia

[7] Univ New South Wales, Sch Psychol, Sydney, NSW, Australia

[8] Univ Florida, Ctr Arts Med, Interdisciplinary Res Lab, Gainesville, FL USA

[9] Vanderbilt Univ, Med Ctr, Dept Neurol, Vanderbilt Mem & Alzheimers Ctr, Nashville, TN USA

[10] Vanderbilt Univ, Med Ctr, Vanderbilt Genet Inst, Nashville, TN USA

[11] Rush Univ, Med Ctr, Rush Inst Hlth Aging, Chicago, IL USA

[12] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL USA

[13] Mayo Clin, Dept Radiol, Rochester, MN USA

[14] Univ Fed Rio Grande Do Sul, Grad Program Biol Sci Biochem, Porto Alegre, Brazil

[15] Thomas Jefferson Univ, Jefferson Coll Populat Hlth, Philadelphia, PA USA

[16] Univ Southern Calif, Network Life Course & Hlth Dynam & Dispar, Los Angeles, CA USA

[17] Laurentian Univ, Sudbury, ON, Canada

[18] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA

[19] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[20] Murdoch Univ, Hlth Futures Inst, Ctr Hlth Ageing, Murdoch, WA, Australia

[21] Murdoch Univ, Sch Psychol, Murdoch, WA, Australia

[22] Royal Melbourne Hosp, Neuropsychiat Ctr, Parkville, Vic, Australia

[23] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia

[24] Univ Barcelona, Fac Med & Hlth Sci, Dept Med, Barcelona, Spain

[25] Univ Barcelona, Inst Neurociencies, Barcelona, Spain

[26] Inst Invest Biomed IDIBAPS, Barcelona, Spain

[27] Univ Autonoma Barcelona, Inst Guttmann, Inst Univ Neurorehabil Adscrit, Badalona, Barcelona, Spain

[28] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[29] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA USA

[30] Univ Calif San Francisco, Biomed & Neurosci Grad Programs, San Francisco, CA USA

[31] Univ Wisconsin, Alzheimers Dis Res Ctr, Sch Med & Publ Hlth, Madison, WI USA

[32] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI USA

[33] Ludwig Maximilians Univ LMU, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

[34] German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 08期

关键词：

brain maintenance; cardiovascular; cognitive decline; cognitive reserve; education; genetics; inequalities; lifestyle; TDP43; APOLIPOPROTEIN-E GENOTYPE; SMALL VESSEL DISEASE; WHITE-MATTER; RISK-FACTORS; BRAIN STRUCTURE; APOE EPSILON-4; OLDER-ADULTS; PERIVASCULAR SPACES; CORTICAL THICKNESS; PHYSICAL-ACTIVITY;

D O I：

10.1002/alz.13844

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sex and gender-biological and social constructs-significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular disease) which ultimately shape cognitive trajectories. Understanding the interplay of these factors is central to understanding resilience and resistance mechanisms explaining maintained cognitive function and reduced pathology accumulation in aging and AD. In this narrative review, the ADDRESS! Special Interest Group (Alzheimer's Association) adopted a multidisciplinary approach to provide the foundations and recommendations for future research into sex- and gender-specific drivers of resilience, including a sex/gender-oriented review of risk factors, genetics, AD and non-AD pathologies, brain structure and function, and animal research. We urge the field to adopt a sex/gender-aware approach to resilience to advance our understanding of the intricate interplay of biological and social determinants and consider sex/gender-specific resilience throughout disease stages.Highlights Sex differences in resilience to cognitive decline vary by age and cognitive status. Initial evidence supports sex-specific distinctions in brain pathology. Findings suggest sex differences in the impact of pathology on cognition. There is a sex-specific change in resilience in the transition to clinical stages. Gender and sex factors warrant study: modifiable, immune, inflammatory, and vascular.

引用

页码：5695 / 5719

页数：25

共 271 条

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