Histo- and Molecular Pathology of gastroenteropancreatic neuroendocrine Neoplasms

被引：0

作者：

Kellers, Franziska ^{[1
]}

Schulte, Dominik Maria ^{[2
,3
,4
]}

Jesinghaus, Moritz ^{[5
]}

Konukiewitz, Bjoern ^{[6
,7
]}

机构：

[1] Christian Albrechts Univ Kiel, Univ klinikum Schleswig Holstein, Inst Pathol, Pathol, Kiel, Germany

[2] Univ Klinikum Schleswig Holstein, Abt Endokrinol Diabetol & Klin Ernahrungsmedizin, Klin Innere Med, Campus Kiel, Kiel, Germany

[3] Univ Klinikum Schleswig Holstein, Inst Diabetol & Klin Stoffwechselforschung, Campus Kiel, Kiel, Germany

[4] Lipidologie DGFF, Innere Med Endokrinol, Diabetol, Ernahrungsmed, Kiel, Germany

[5] Philipps Univ Marburg, Univ Klinikum Giessen & Marburg, Inst Pathol, Marburg, Germany

[6] Univ Klinikum Schleswig Holstein, Inst Pathol, Campus Kiel, Kiel, Germany

[7] Christian Albrechts Univ Kiel, Translat Pathol, Kiel, Germany

来源：

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2024年 / 149卷 / 15期

关键词：

neuroendokriner Tumor; Neoplasie; Ki67; Molekularpathologie; neuroendocrine tumor; neuroendocrine carcinoma; neoplasm; molecular pathology; EXPRESSION; TUMORS; PANCREAS; MEN1; CELL; CARCINOMAS; RELEVANCE; CRITERIA; DUODENUM; DISTINCT;

D O I：

10.1055/a-2157-5460

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pathological differentiation of neuroendocrine neoplasias (NEN) makes an important contribution to primary diagnosis and can provide the decisive clue to the primary tumor in the metastatic situation where the primary tumor is unclear. Histological and molecular pathological features of NEN can be included in clinical-therapeutic management and are presented below for NEN of the gastroenteropancreatic system.

引用

页码：887 / 893

页数：7

共 34 条

[1] Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1:: Criteria, molecular concepts and clinical significance [J].

Anlauf, Martin ;

Perren, Aurel ;

Kloeppel, Guenter .

PATHOBIOLOGY, 2007, 74 (05) :279-284

[2] Sporadic versus hereditary gastrinomas of the duodenum and pancreas:: Distinct clinico-pathological and epidemiological features [J].

Anlauf, Martin ;

Garbrecht, Nele ;

Henopp, Tobias ;

Schmitt, Anja ;

Schlenger, Regina ;

Raffel, Andreas ;

Krausch, Markus ;

Gimm, Oliver ;

Eisenberger, Claus F. ;

Knoefel, Wolfram T. ;

Dralle, Henning ;

Komminoth, Paul ;

Heitz, Philipp U. ;

Perren, Aurel ;

Kloeppel, Guenter .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (34) :5440-5446

[3]

[Anonymous], 2017, WHO classification of tumours: pathology and genetics of tumours of endocrine organs

[4]

Bräutigam K, 2024, PATHOLOGIE, DOI 10.1007/s00292-023-01276-4

[5] MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases [J].

Corbo, Vincenzo ;

Dalai, Irene ;

Scardoni, Maria ;

Barbi, Stefano ;

Beghelli, Stefania ;

Bersani, Samantha ;

Albarello, Luca ;

Doglioni, Claudio ;

Schott, Christina ;

Capelli, Paola ;

Chilosi, Marco ;

Boninsegna, Letizia ;

Becker, Karl-Friedrich ;

Falconi, Massimo ;

Scarpa, Aldo .

[6] Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression [J].

Di Domenico, Annunziata ;

Pipinikas, Christodoulos P. ;

Maire, Renaud S. ;

Braeutigam, Konstantin ;

Simillion, Cedric ;

Dettmer, Matthias S. ;

Vassella, Erik ;

Thirlwell, Chrissie ;

Perren, Aurel ;

Marinoni, Ilaria .

COMMUNICATIONS BIOLOGY, 2020, 3 (01)

[7] PITX2 as a Sensitive and Specific Marker of Midgut Neuroendocrine Tumors: Results from a Cohort of 1157 Primary Neuroendocrine Neoplasms [J].

Grass, Albert ;

Kasajima, Atsuko ;

Foersch, Sebastian ;

Kriegsmann, Mark ;

Brobeil, Alexander ;

Schmitt, Maxime ;

Wagner, Daniel ;

Poppinga, Jelte ;

Wiese, Dominik ;

Maurer, Elisabeth ;

Kirschbaum, Andreas ;

Muley, Thomas ;

Winter, Hauke ;

Rinke, Anja ;

Gress, Thomas M. ;

Kremer, Markus ;

Evert, Matthias ;

Maerkl, Bruno ;

Quaas, Alexander ;

Eckstein, Markus ;

Tschurtschenthaler, Markus ;

Kloeppel, Guenter ;

Denkert, Carsten ;

Bartsch, Detlef K. ;

Jesinghaus, Moritz .

MODERN PATHOLOGY, 2024, 37 (04)

[8] An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets [J].

Griger, Joscha ;

Widholz, Sebastian A. ;

Jesinghaus, Moritz ;

Kraetzig, Niklas de Andrade ;

Lange, Sebastian ;

Engleitner, Thomas ;

Montero, Juan Jose ;

Zhigalova, Ekaterina ;

Oellinger, Rupert ;

Suresh, Veveeyan ;

Winkler, Wiebke ;

Lier, Svenja ;

Baranov, Olga ;

Trozzo, Riccardo ;

Ben Khaled, Najib ;

Chakraborty, Shounak ;

Yu, Jiakun ;

Konukiewitz, Bjoern ;

Steiger, Katja ;

Pfarr, Nicole ;

Rajput, Ashish ;

Sailer, David ;

Keller, Gisela ;

Schirmacher, Peter ;

Roecken, Christoph ;

Fagerstedt, Klaus W. ;

Mayerle, Julia ;

Schmidt-Supprian, Marc ;

Schneider, Guenter ;

Weichert, Wilko ;

Calado, Dinis P. ;

Sommermann, Thomas ;

Kloeppel, Gueuronter ;

Rajewsky, Klaus ;

Saur, Dieter ;

Rad, Roland .

CANCER CELL, 2023, 41 (07) :1327-+

[9] Aberrant Menin expression is an early event in pancreatic neuroendocrine tuniorigenesis [J].

Hackeng, Wenzel M. ;

Brosens, Lodewijk A. A. ;

Poruk, Katherine E. ;

Noe, Michael ;

Hosoda, Waki ;

Poling, Justin S. ;

Rizzo, Anthony ;

Campbell-Thompson, Martha ;

Atkinson, Mark A. ;

Konukiewitz, Bjoern ;

Kloeppel, Guenter ;

Heaphy, Christopher M. ;

Meeker, Alan K. ;

Wood, Laura D. .

HUMAN PATHOLOGY, 2016, 56 :93-100

[10] Morphology Matters A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases [J].

Jesinghaus, Moritz ;

Schmitt, Maxime ;

Lang, Corinna ;

Reiser, Marianne ;

Scheiter, Alexander ;

Konukiewitz, Bjoern ;

Steiger, Katja ;

Silva, Miguel ;

Tschurtschenthaler, Markus ;

Lange, Sebastian ;

Foersch, Sebastian ;

Becker, Karl F. ;

Saur, Dieter ;

Friess, Helmut ;

Halfter, Kathrin ;

Engel, Jutta ;

Boxberg, Melanie ;

Pfarr, Nicole ;

Wilhelm, Dirk ;

Weichert, Wilko .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2021, 45 (07) :969-978

← 1 2 3 4 →