Can Affinity of Hemoglobin to Oxygen to be a Prognostic Marker in Critically ill COVID-19 patients?

被引:0
作者
Alay, G. H. [1 ]
Tatlisuluoglu, D. [1 ]
Turan, G. [1 ]
机构
[1] Basaksehir Cam & Sakura City Hosp, Intens Care Unit, Istanbul, Turkiye
关键词
Acute respiratory distress syndrome; COVID-19; critical illness; hemoglobin oxygen dissociation curve; mortality; DISSOCIATION CURVE; ANEMIA; SEPSIS; BLOOD;
D O I
10.4103/njcp.njcp_581_22
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: This study's objective is to determine the slope of the hemoglobin oxygen dissociation curve in critically ill patients who have COVID-19 along with blood gas measurements and how mortality might be impacted by this circumstance. Aim: It has been reported that the hemoglobin oxygen dissociation curve is not different from healthy patients in COVID-19. However, there are insufficient data on the behavior of the curve in patients who require intensive care. Patients and Methods: This retrospective study was conducted between 01.03.2021 and 01.07.2021 with patients who were followed up due to COVID-19 in adult intensive care unit. P50 and lactate value obtained from in vitro calculated blood gas analysis. The survival status of the patients was recorded. Results: The mean P50 value at the admission of nonsurvivors was significantly higher than survivors. In correlation analysis, a significant positive correlation was seen between P50, mortality, and lactate level at admission. SpO(2), PaO2/FiO(2) ratio, and length of stay in intensive care unit were significantly negatively correlated with P50 levels. Conclusion: A right shift in the hemoglobin oxygen dissociation curve is associated with mortality. Lactate levels were also associated with a right shift. Prospective experimental studies are needed to provide a better understanding of this process.
引用
收藏
页码:731 / 736
页数:6
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