Altered Metabolism and Inflammation Driven by Post-translational Modifications in Intervertebral Disc Degeneration

被引：8

作者：

Zhu, Dingchao ^{[1
]}

Liang, Huaizhen ^{[1
]}

Du, Zhi ^{[1
]}

Liu, Qian ^{[2
]}

Li, Gaocai ^{[1
]}

Zhang, Weifeng ^{[1
]}

Wu, Di ^{[1
]}

Zhou, Xingyu ^{[1
]}

Song, Yu ^{[1
]}

Yang, Cao ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan 430022, Hubei, Peoples R China

[2] Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China

来源：

RESEARCH | 2024年 / 7卷

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE STRESS; MATRIX DEGRADATION; RAG GTPASES; ACETYLATION; HOMEOSTASIS; SIRT3; AMPK; PHOSPHORYLATION; UBIQUITINATION; METHYLATION;

D O I：

10.34133/research.0350

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain and a leading contributor to disability. IVDD progression involves pathological shifts marked by low-grade inflammation, extracellular matrix remodeling, and metabolic disruptions characterized by heightened glycolytic pathways, mitochondrial dysfunction, and cellular senescence. Extensive posttranslational modifications of proteins within nucleus pulposus cells and chondrocytes play crucial roles in reshaping the intervertebral disc phenotype and orchestrating metabolism and inflammation in diverse contexts. This review focuses on the pivotal roles of phosphorylation, ubiquitination, acetylation, glycosylation, methylation, and lactylation in IVDD pathogenesis. It integrates the latest insights into various posttranslational modification-mediated metabolic and inflammatory signaling networks, laying the groundwork for targeted proteomics and metabolomics for IVDD treatment. The discussion also highlights unexplored territories, emphasizing the need for future research, particularly in understanding the role of lactylation in intervertebral disc health, an area currently shrouded in mystery.

引用

页数：17

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