Differential rearing alters Fos in the accumbens core and ventral palidum following reinstatement of cocaine seeking in male Sprague-Dawley rats

被引：0
|
作者：
Orban, Z. [1 ]
Gill, M. J. [1 ]
机构：
[1] North Cent Coll, Dept Psychol & Neurosci, 30 N Brainard St, Naperville, IL 60540 USA
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2024年 / 243卷
关键词：
Differential rearing; Environmental enrichment; Self-administration; Cocaine; Reinstatement; CUE-INDUCED REINSTATEMENT; NUCLEUS-ACCUMBENS; ENVIRONMENTAL ENRICHMENT; C-FOS; PRIMED REINSTATEMENT; REDUCES COCAINE; TEGMENTAL AREA; AMPHETAMINE; ACTIVATION; EXPRESSION;
D O I：
10.1016/j.pbb.2024.173837
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Rearing rats in environmental enrichment produces a protective effect when exposed to stimulants, as enriched rats display attenuated cocaine seeking during reinstatement. However, less is known about what changes in the brain are responsible for this protective effect. The current study investigated differences in Fos protein expression following reinstatement of cocaine seeking in differentially reared rats. Rats were reared in either enriched (EC) or impoverished (IC) conditions for 30 days, after which rats self-administered cocaine in 2-h sessions. Following self-administration, rats underwent extinction and cue-induced or cocaine-primed reinstatement of cocaine seeking, brains were extracted, and Fos immunohistochemistry was performed. IC rats sought cocaine significantly more than EC rats during cue-induced reinstatement, and cocaine seeking was positively correlated with Fos expression in the nucleus accumbens core and ventral pallidum. IC rats displayed greater Fos expression than EC rats in the accumbens and ventral pallidum, suggesting a role of these areas in the enrichment-induced protective effect.
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页数：8
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