Ganospirones A-G, seven undescribed spiro-meroterpenoids from Ganoderma lucidum and their biological activities

被引：0

作者：

Li, Dan ^{[2
]}

Li, Sheng-Hong ^{[1
]}

Gao, Qiang ^{[1
]}

Luo, Qi ^{[2
]}

Cheng, Yong-Xian ^{[1
]}

机构：

[1] Shenzhen Univ, Shenzhen Univ Med Sch, Marshall Lab Biomed Engn,Guangdong Prov Key Lab Ch, Inst Inheritance Based Innovat Chinese Med,Sch Pha, Shenzhen 518060, Peoples R China

[2] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China

来源：

PHYTOCHEMISTRY | 2024年 / 227卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma lucidum; Ganodermataceae; Meroterpenoids; Ganospirones A -G; Anti-inflammatory; Renal fibrosis; TRITERPENOIDS; METABOLITES;

D O I：

10.1016/j.phytochem.2024.114226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ganoderma lucidum, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A-G (1-7), seven pairs of undescribed spiro-meroterpenoids, were isolated from the fruiting bodies of G. lucidum. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and antirenal fibrosis activities of the meroterpenoids 1-7 were tested, and the results revealed that (-)-2 and (+)-2 could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 mu M.

引用

页数：9

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