The multifaceted roles of perlecan in fibrosis

被引：39
作者：
Lord, Megan S. [1 ]
Tang, Fengying [1 ]
Rnjak-Kovacina, Jelena [1 ]
Smith, James G. W. [2 ]
Melrose, James [1 ,3 ,4 ]
Whitelock, John M. [1 ]
机构：
[1] UNSW Sydney, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia
[2] Univ Nottingham, Nottingham NG7 2RD, England
[3] Kolling Inst Northern Sydney Local Hlth Dist, Raymond Purves Bone & Joint Res Lab, St Leonards, NSW 2065, Australia
[4] Univ Sydney, Royal North Shore Hosp, Sydney Med Sch, St Leonards, NSW 2065, Australia
来源：
MATRIX BIOLOGY | 2018年 / 68-69卷
基金：
澳大利亚研究理事会;
关键词：
Fibrosis; Proteoglycan; Perlecan; Heparan sulfate; SMOOTH-MUSCLE-CELLS; HEPARAN-SULFATE PROTEOGLYCANS; FIBROBLAST-GROWTH-FACTOR; IDIOPATHIC PULMONARY-FIBROSIS; HEPATIC STELLATE CELLS; EXTRACELLULAR-MATRIX PROTEINS; HUMAN LUNG FIBROBLASTS; BASEMENT-MEMBRANE; ENDOTHELIAL-CELLS; GENE-EXPRESSION;
D O I：
10.1016/j.matbio.2018.02.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix. This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：150 / 166
页数：17
相关论文
共 213 条
  • [21] Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
    Cailhier, Jean-Francois
    Sirois, Isabelle
    Laplante, Patrick
    Lepage, Stephanie
    Raymond, Marc-Andre
    Brassard, Nathalie
    Prat, Alexandre
    Iozzo, Renato V.
    Pshezhetsky, Alexey V.
    Hebert, Marie-Josee
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (40) : 27220 - 27229
  • [22] Case AH, 2017, BMJ OPEN RESPIR RES, V4, DOI 10.1136/bmjresp-2017-000192
  • [23] Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers
    Cassiman, D
    Libbrecht, L
    Desmet, V
    Denef, C
    Roskams, T
    [J]. JOURNAL OF HEPATOLOGY, 2002, 36 (02) : 200 - 209
  • [24] Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion
    Celie, Johanna W. A. M.
    Rutjes, Niels W. P.
    Keuning, Eelco D.
    Soininen, Raija
    Heljasvaara, Ritva
    Pihlajaniemi, Taina
    Drager, Angelika M.
    Zweegman, Sonja
    Kessler, Floortje L.
    Beelen, Robert H. J.
    Florquin, Sandrine
    Aten, Jan
    van den Born, Jacob
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (06) : 1865 - 1878
  • [25] Ceol M, 2000, J AM SOC NEPHROL, V11, P2324, DOI 10.1681/ASN.V11122324
  • [26] RECOMBINANT DOMAIN-III OF PERLECAN PROMOTES CELL ATTACHMENT THROUGH ITS RGDS SEQUENCE
    CHAKRAVARTI, S
    HORCHAR, T
    JEFFERSON, B
    LAURIE, GW
    HASSELL, JR
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) : 404 - 409
  • [27] HCV and HIV co-infection: mechanisms and management
    Chen, Jennifer Y.
    Feeney, Eoin R.
    Chung, Raymond T.
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2014, 11 (06) : 362 - 371
  • [28] The pathogenesis of COPD and IPF: Distinct horns of the same devil?
    Chilosi, Marco
    Poletti, Venerino
    Rossi, Andrea
    [J]. RESPIRATORY RESEARCH, 2012, 13
  • [29] Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells
    Chuang, Christine Y.
    Degendorfer, Georg
    Hammer, Astrid
    Whitelock, John M.
    Malle, Ernst
    Davies, Michael J.
    [J]. BIOCHEMICAL JOURNAL, 2014, 459 : 313 - 322
  • [30] Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan
    Chuang, Christine Y.
    Lord, Megan S.
    Melrose, James
    Rees, Martin D.
    Knox, Sarah M.
    Freeman, Craig
    Iozzo, Renato V.
    Whitelock, John M.
    [J]. BIOCHEMISTRY, 2010, 49 (26) : 5524 - 5532
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